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    ORALLY DISINTEGRATING TABLET
    2.
    发明申请
    ORALLY DISINTEGRATING TABLET 有权
    ORALLY DISINCAGE TABLET

    公开(公告)号：US20130295175A1

    公开(公告)日：2013-11-07

    申请号：US13803527

    申请日：2013-03-14

    Applicant: MCNEIL-PPC, INC.

    Inventor： Jen-Chi Chen ,  Kenneth Day ,  Christopher E. Szymczak

    IPC: A61K9/20 ,  A61K31/426 ,  A61K31/167

    CPC classification number: A61K9/2081 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2095 ,  A61K31/167 ,  A61K31/426 ,  A61K31/7004 ,  A61K2300/00

    Abstract: The present invention features a tablet containing at least one first material, at least one second material, and at least one pharmaceutically active agent, wherein:(a) the first material is a dielectric water-containing material (i) containing from about 1 to about 5 percent, by weight, of bound water and (ii) having a dielectric loss, when measured at a density of between 0.15 and 0.5 g/cc, of from about 0.05 to about 0.7; and(b) the second material (i) having a water solubility from about 20 to about 400 g per 100 g of water at 25° C., (ii) having a dielectric loss, when measured at a density between 0.5 and 1 g/cc, of less than about 0.05.

    Abstract translation: 本发明的特征在于含有至少一种第一材料，至少一种第二种材料和至少一种药物活性剂的片剂，其中：（a）第一种材料是含电介质水的材料（i），其含有约1至 约0.05％（重量）的结合水和（ii）当以0.15-0.5g / cc的密度测量时介电损耗为约0.05至约0.7; 和（b）第二材料（i）在25℃下具有约20至约400g / 100g水的水溶性，（ii）当介于0.5和1g之间的密度 / cc，小于约0.05。

    Modified release analgesic suspensions
    4.
    发明授权
    Modified release analgesic suspensions 有权
    改性释放止痛剂悬浮液

    公开(公告)号：US08771716B2

    公开(公告)日：2014-07-08

    申请号：US13755749

    申请日：2013-01-31

    Applicant: McNeil-PPC, Inc.

    Inventor： Der-Yang Lee ,  Jen-Chi Chen ,  Vincent Chen ,  Robert Shen

    IPC: A61K31/785

    CPC classification number: A61K9/5084 ,  A61K9/0095 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5073 ,  A61K31/137 ,  A61K31/192 ,  A61K45/06 ,  A61K47/585 ,  A61K2300/00

    Abstract: A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.

    Abstract translation: 提供包含非甾体抗炎药物，特别是丙酸衍生物如布洛芬的药物剂型，以及具有较短治疗有效血浆浓度持续时间的第二活性成分，例如去氧肾上腺素及其施用方法 。 该方法在延长的时间段内提供改善的治疗效果，特别是与减充血剂缓解一起的疼痛缓解。

    TABLET COMPRISING A FIRST AND SECOND REGION
    5.
    发明申请
    TABLET COMPRISING A FIRST AND SECOND REGION 审中-公开
    包含第一和第二地区的图纸

    公开(公告)号：US20130295174A1

    公开(公告)日：2013-11-07

    申请号：US13804109

    申请日：2013-03-14

    Applicant: MCNEIL-PPC, INC.

    Inventor： Harry S. Sowden ,  Gerard P. McNally ,  Oliver Anderson ,  William J. Stuhl ,  Jen-Chi Chen ,  Kenneth Day ,  Christopher E. Szymczak

    IPC: A61K9/24 ,  A61K31/137 ,  A61K31/167 ,  A61K9/20 ,  A61K31/4545

    CPC classification number: A61K9/209 ,  A61K9/0056 ,  A61K9/2072 ,  A61K9/2086 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4545 ,  A61K2300/00

    Abstract: In one aspect, the present invention features a tablet including a first region and a second region, wherein: (i) the first region and the second region each include at least 10%, by volume, of the tablet; (ii) the first region includes a pharmaceutically active agent and the composition of the first region is different from the composition of the second region; (iii) the first region has a density less than about 0.8 g/cc; and (iv) the first region disintegrates in the mouth when placed on the tongue in less than about 30 seconds; wherein the shape of the tablet includes two opposing major faces separated by a side wall, and the interface between the first region and the second region is along at least one major face of the tablet.

    Abstract translation: 在一个方面，本发明的特征在于包括第一区域和第二区域的片剂，其中：（i）第一区域和第二区域各自包含片剂的至少10体积％ （ii）第一区域包括药物活性剂，第一区域的组成与第二区域的组成不同; （iii）第一区域的密度小于约0.8g / cc; 和（iv）第一个区域在不到约30秒内放置在舌头上时在口中分解; 其中所述片剂的形状包括由侧壁分开的两个相对的主面，并且所述第一区域和所述第二区域之间的界面沿着所述片剂的至少一个主面。

    Modified Release Analgesic Suspensions
    6.
    发明申请
    Modified Release Analgesic Suspensions 有权
    改性释放镇痛药悬浮液

    公开(公告)号：US20130142846A1

    公开(公告)日：2013-06-06

    申请号：US13755749

    申请日：2013-01-31

    Applicant: MCNEIL-PPC, INC

    Inventor： Der-Yang Lee ,  Jen-Chi Chen ,  Vincent Chen ,  Robert Shen

    IPC: A61K9/50

    CPC classification number: A61K9/5084 ,  A61K9/0095 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5073 ,  A61K31/137 ,  A61K31/192 ,  A61K45/06 ,  A61K47/585 ,  A61K2300/00

    Abstract: A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.

    Abstract translation: 提供包含非甾体抗炎药物，特别是丙酸衍生物如布洛芬的药物剂型，以及具有较短治疗有效血浆浓度持续时间的第二活性成分，例如去氧肾上腺素及其施用方法 。 该方法在延长的时间段内提供改善的治疗效果，特别是与减充血剂缓解一起的疼痛缓解。

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