Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
    1.
    发明授权
    Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds 有权
    取代的4-氨基-1-(吡啶基甲基)哌啶及相关化合物

    公开(公告)号:US08030502B2

    公开(公告)日:2011-10-04

    申请号:US11974982

    申请日:2007-10-17

    IPC分类号: C07D207/08

    CPC分类号: C07D401/14

    摘要: This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.

    摘要翻译: 本发明提供了可用作毒蕈碱受体拮抗剂的4-氨基-1-(吡啶基甲基)哌啶及其相关化合物及其药学上可接受的盐。 本发明还提供含有这些化合物的药物组合物; 用于制备这些化合物的方法和中间体; 以及使用这些化合物治疗由毒蕈碱受体介导的疾病状况的方法,例如膀胱过度活动,肠易激综合征和慢性阻塞性肺疾病。

    Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
    2.
    发明申请
    Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds 有权
    取代的4-氨基-1-(吡啶基甲基)哌啶及相关化合物

    公开(公告)号:US20080091034A1

    公开(公告)日:2008-04-17

    申请号:US11974982

    申请日:2007-10-17

    IPC分类号: C07D207/08

    CPC分类号: C07D401/14

    摘要: This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.

    摘要翻译: 本发明提供了可用作毒蕈碱受体拮抗剂的4-氨基-1-(吡啶基甲基)哌啶及其相关化合物及其药学上可接受的盐。 本发明还提供含有这些化合物的药物组合物; 用于制备这些化合物的方法和中间体; 以及使用这些化合物治疗由毒蕈碱受体介导的疾病状况的方法,例如膀胱过度活动,肠易激综合征和慢性阻塞性肺疾病。