公开(公告)号：US10994025B2

公开(公告)日：2021-05-04

申请号：US15977778

申请日：2018-05-11

Applicant: Massachusetts Institute of Technology

Inventor： Jiahe Li ,  Paula T. Hammond ,  Yanpu He ,  Wade Wang

IPC: A61K48/00 ,  C12N15/113 ,  A61K9/00 ,  A61K38/17 ,  A61K47/42 ,  C12N15/11

Abstract: The invention relates to methods of improving efficacy and enhancing silencing of target genes using Ago2 protein-dsRNA complex (RNP) of the invention.

公开(公告)号：US20180326092A1

公开(公告)日：2018-11-15

申请号：US15977778

申请日：2018-05-11

Applicant: Massachusetts Institute of Technology

Inventor： Jiahe Je ,  Paula T. Hammond ,  Yanpu He ,  Wade Wang

IPC: A61K48/00 ,  C12N15/113 ,  A61K9/00 ,  A61K38/17 ,  A61K47/42

CPC classification number: A61K48/005 ,  A61K9/0019 ,  A61K38/17 ,  A61K47/42 ,  A61K48/0075 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/121 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/31 ,  C12N2310/333 ,  C12N2310/3341 ,  C12N2310/335 ,  C12N2310/336 ,  C12N2320/35

Abstract: The invention relates to methods of improving efficacy and enhancing silencing of target genes using Ago2 protein-dsRNA complex (RNP) of the invention.