公开(公告)号：US20060003933A1

公开(公告)日：2006-01-05

申请号：US11145587

申请日：2005-06-06

Applicant: Martin Friedlander ,  Hilda Aguilar ,  Michael Dorrell

Inventor： Martin Friedlander ,  Hilda Aguilar ,  Michael Dorrell

IPC: A61K38/47 ,  A61K31/7072 ,  A61K31/538

CPC classification number: A61K31/7072 ,  A61K9/0048 ,  A61K31/538 ,  A61K38/00 ,  A61K45/06 ,  C12N9/93 ,  C12Y601/01002 ,  A61K2300/00

Abstract: The present invention provides compositions and methods of treating neovascular diseases, such as a retinal neovascular diseases and tumors, by administering to a patient suffering from a neovascular disease or tumor a vascular development inhibiting amount of a combination of the angiogenesis suppressing drugs comprising an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS) and at least one compound selected from the group consisting of a vascular endothelial growth factor (VEGF) signaling inhibitor and an integrin signaling inhibitor. Compositions for use in the methods include an admixture of an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS) and at least one of a vascular endothelial growth factor (VEGF) signaling inhibitor and an integrin signaling inhibitor, together with a pharmaceutically acceptable excipient.