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公开(公告)号：US4710320A
公开(公告)日：1987-12-01
申请号：US753860
申请日：1985-07-11
Applicant: Makoto Hattori , Masao Nishikuri , Yasuyoshi Ueda
Inventor： Makoto Hattori , Masao Nishikuri , Yasuyoshi Ueda
Abstract: 1-Amino-2-phenoxy-4-hydroxyanthraquinones, which are useful as a red disperse dye for polyester fibers, and also useful as an intermediate for the production of other red disperse dyes, are produced in a high yield and purity by reacting a 1-amino-2-halogeno-4-hydroxyanthraquinone with a phenol compound in a sulfane solvent in the presence of an acid binding agent.
Abstract translation: 可用作聚酯纤维的红色分散染料，也可用作生产其它红色分散染料的中间体的1-氨基-2-苯氧基-4-羟基蒽醌以高产率和纯度通过使 1-氨基-2-卤代-4-羟基蒽醌与酚化合物在硫酸溶剂中在酸结合剂存在下反应。
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公开(公告)号：US09388109B2
公开(公告)日：2016-07-12
申请号：US14129003
申请日：2012-06-21
Applicant: Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
Inventor： Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
IPC: A61K31/12 , C07C49/577 , A23L2/52 , A23K1/16 , A23L1/30 , A61K8/34 , A61Q19/00 , C07C45/81 , C07C41/40 , C07C41/46 , C07C43/23
CPC classification number: C07C49/577 , A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K8/347 , A61K9/28 , A61K31/122 , A61Q19/00 , C07C41/40 , C07C41/46 , C07C43/23 , C07C45/81
Abstract: With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.
Abstract translation: 关于还原型辅酶Q10，没有关于晶体多晶型的存在的报道，已经认为常规获得的晶体形式仅是一种形式。 本发明涉及在通过差示扫描量热法（DSC）以5℃/ min的速率升温的温度升高期间具有指示在54±2℃熔化的吸热峰的还原型辅酶Q10晶体和/或还原型辅酶Q10晶体 通过粉末X射线（Cu-Kα）衍射，辅助Q10晶体在衍射角（2θ;±0.2°）为11.5°，18.2°，19.3°，22.3°，23.0°和33.3°处显示出特征峰。 晶体形式是在溶剂中具有较高熔点和较低溶解度的新型还原型辅酶Q10晶体，其稳定性优于常规已知的还原型辅酶Q10晶体。
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公开(公告)号：US09315839B2
公开(公告)日：2016-04-19
申请号：US13020500
申请日：2011-02-03
Applicant: Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
Inventor： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
Abstract: The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
Abstract translation: 本发明涉及一种还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有还原型辅酶Q10比例不小于70摩尔％的微生物细胞，任选地破坏细胞并回收所生成的还原型辅酶Q10。 本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至 此后氧化由此得到的还原型辅酶Q10。 根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。
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公开(公告)号：US08067217B2
公开(公告)日：2011-11-29
申请号：US11315161
申请日：2005-12-23
Applicant: Takahiro Ueda , Tadao Ono , Shiro Kitamura , Yasuyoshi Ueda
Inventor： Takahiro Ueda , Tadao Ono , Shiro Kitamura , Yasuyoshi Ueda
IPC: C12N9/98
CPC classification number: A61K9/4816
Abstract: The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.
Abstract translation: 本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法，所述还原型辅酶Q10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药物， 补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q10的方法，其包括制备或获得含有还原型辅酶Q10的胶囊，并且将胶囊周围的环境控制在相对湿度不小于0％但不超过 超过60％。 根据该方法，可以稳定地保持还原型辅酶Q10，而不需要巨大的成本和劳动力，或特殊设备。
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5.发明申请METHOD OF PRODUCING REDUCED COENZYME Q10 CRYSTALS WITH EXCELLENT HANDLING PROPERTIES 有权生产具有优异处理性能的还原型COYZYME Q10水晶的方法公开(公告)号：US20110263906A1
公开(公告)日：2011-10-27
申请号：US13176479
申请日：2011-07-05
Applicant: Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
Inventor： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC: C07C41/40
Abstract: The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.
Abstract translation: 本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。 根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。 此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。 因此，可以高产率获得高纯度还原型辅酶Q10。
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Patent Agency Ranking
公开(公告)号：US07897169B2
公开(公告)日：2011-03-01
申请号：US10501669
申请日：2003-01-20
Applicant: Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
Inventor： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
IPC: A61K47/00
CPC classification number: A23G9/32 , A21D2/14 , A23C11/04 , A23C19/082 , A23D7/0056 , A23D7/015 , A23D9/007 , A23F3/163 , A23F5/243 , A23L7/111 , A23L7/122 , A23L7/13 , A23L7/165 , A23L9/12 , A23L9/22 , A23L19/03 , A23L19/14 , A23L23/00 , A23L27/60 , A23L33/10 , A23P20/11 , A23P30/40 , A23V2002/00 , C11B5/0092 , A23V2250/314
Abstract: To provide a food which suitably supply ubiquinol, a substance indispensable to the living body but is liable to be decreased and fall short of the requirements, through ingestion in the same ways as the ordinary foods in daily living. A ubiquinol-enriched oil/fat-containing food.
Abstract translation: 提供适当地提供泛醌的食物，其通过以与日常生活中的普通食物相同的方式摄取，这是生物体不可缺少但易于降低并且不符合要求的物质。 富含ubiquinol的含油/脂肪的食物。
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7.发明授权Peroxisome proliferator activated receptor ligand and process for producing the same 失效过氧化物酶体增殖物激活受体配体及其制备方法公开(公告)号：US07524975B2
公开(公告)日：2009-04-28
申请号：US10490641
申请日：2002-10-11
Applicant: Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
Inventor： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
IPC: C07D311/00
CPC classification number: C07D311/06 , A23K20/111 , A23K20/121 , A23K50/00 , A23K50/40 , A23L33/10 , A23L33/105 , A61K31/12 , A61K31/353 , A61K31/37 , A61K36/484 , A61K2300/00
Abstract: The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.
Abstract translation: 本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。 本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质， 食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。
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8.发明授权Method of collecting highly pure polyhydroxyalkanoate from microbial cells 有权从微生物细胞中收集高纯度聚羟基链烷酸酯的方法公开(公告)号：US07393668B2
公开(公告)日：2008-07-01
申请号：US10541389
申请日：2004-01-20
Applicant: Yoshifumi Yanagita , Noriko Ogawa , Yasuyoshi Ueda , Fumio Osakada , Keiji Matsumoto
Inventor： Yoshifumi Yanagita , Noriko Ogawa , Yasuyoshi Ueda , Fumio Osakada , Keiji Matsumoto
CPC classification number: C12P7/625
Abstract: The present invention has an object to provide a method for separating and purifying a PHA without causing a serious decrease of the molecular weight to obtain a highly pure PHA in a high yield, which comprises efficiently removing cell components other than PHA particles from a cultured PHA-containing microbial cell. Another object of the present invention is to provide a method for obtaining an agglomerate of PHA particles.The method for recovering a PHA according to the present invention is a method which comprises efficiently disrupting a cell to recover the PHA by carrying out a physical disruption treatment and an alkali addition at low temperature for an aqueous suspension of the PHA-containing microbial cell, and then treating the PHA with an enzyme and/or a surfactant. Moreover, the particle diameter of the PHA may be enlarged by suspending the PHA in a hydrophilic solvent and/or water, and stirring at a temperature equal to or below the boiling point of said suspension, to agglomerate said PHA.
Abstract translation: 本发明的目的是提供一种分离纯化PHA的方法，而不会导致分子量的严重降低以获得高产率的高纯度PHA，其包括从培养的PHA有效除去PHA颗粒以外的细胞成分 含微生物细胞。 本发明的另一个目的是提供一种获得PHA颗粒附聚物的方法。 根据本发明的回收PHA的方法是通过对含PHA的微生物细胞的水性悬浮液进行物理破坏处理和低温碱添加来有效地破坏细胞以回收PHA的方法， 然后用酶和/或表面活性剂处理PHA。 此外，通过将PHA悬浮在亲水溶剂和/或水中并在等于或低于所述悬浮液沸点的温度下搅拌以使所述PHA聚集，可以扩大PHA的粒径。
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公开(公告)号：US20070161825A1
公开(公告)日：2007-07-12
申请号：US11716828
申请日：2007-03-12
Applicant: Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
Inventor： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC: C07C43/20
Abstract: The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently. The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.
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10.发明申请Method of collecting highly pure polyhydroxyalkanoate from microbial cells 有权从微生物细胞中收集高纯度聚羟基链烷酸酯的方法公开(公告)号：US20060084161A1
公开(公告)日：2006-04-20
申请号：US10541389
申请日：2004-01-20
Applicant: Yoshifumi Yanagita , Noriko Ogawa , Yasuyoshi Ueda , Fumio Osakada , Keiji Matsumoto
Inventor： Yoshifumi Yanagita , Noriko Ogawa , Yasuyoshi Ueda , Fumio Osakada , Keiji Matsumoto
IPC: C12N9/00
CPC classification number: C12P7/625
Abstract: The present invention has an object to provide a method for separating and purifying a PHA without causing a serious decrease of the molecular weight to obtain a highly pure PHA in a high yield, which comprises efficiently removing cell components other than PHA particles from a cultured PHA-containing microbial cell. Another object of the present invention is to provide a method for obtaining an agglomerate of PHA particles. The method for recovering a PHA according to the present invention is a method which comprises efficiently disrupting a cell to recover the PHA by carrying out a physical disruption treatment and an alkali addition at low temperature for an aqueous suspension of the PHA-containing microbial cell, and then treating the PHA with an enzyme and/or a surfactant. Moreover, the particle diameter of the PHA may be enlarged by suspending the PHA in a hydrophilic solvent and/or water, and stirring at a temperature equal to or below the boiling point of said suspension, to agglomerate said PHA.
Abstract translation: 本发明的目的是提供一种分离纯化PHA的方法，而不会导致分子量的严重降低以获得高产率的高纯度PHA，其包括从培养的PHA有效除去PHA颗粒以外的细胞成分 含微生物细胞。 本发明的另一个目的是提供一种获得PHA颗粒附聚物的方法。 根据本发明的回收PHA的方法是通过对含PHA的微生物细胞的水性悬浮液进行物理破坏处理和低温碱添加来有效地破坏细胞以回收PHA的方法， 然后用酶和/或表面活性剂处理PHA。 此外，通过将PHA悬浮在亲水溶剂和/或水中并在等于或低于所述悬浮液沸点的温度下搅拌以使所述PHA聚集，可以扩大PHA的粒径。
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