公开(公告)号：US07824868B2

公开(公告)日：2010-11-02

申请号：US12148389

申请日：2008-04-18

Applicant: Magnus Höök ,  Sabitha Prabhakaran

Inventor： Magnus Höök ,  Sabitha Prabhakaran

IPC: G01N33/55 ,  A61K38/16

CPC classification number: C07K14/78 ,  A61K38/00 ,  Y02A50/401

Abstract: Provided herein is a method for inducing formation of a conformationally distinct superfibronectin by contacting plasma fibronectin with BBK32 protein or a BBK32 peptide and the BBK32-induced superfibronectin so formed. Also provided are methods of inhibiting endothelial cell proliferation, of treating pathophysiological conditions associated with endothelial cell proliferation and of inhibiting angiogenesis therein using the BBK32 protein, BBK32 peptide or the BBK32-induced superfibronectin.

Abstract translation: 本文提供通过使血浆纤连蛋白与BBK32蛋白或BBK32肽接触形成的构象不同的超纤连结蛋白和由此形成的BBK32诱导的超纤连结蛋白的方法。 还提供了使用BBK32蛋白，BBK32肽或BBK32诱导的超纤连蛋白来抑制内皮细胞增殖，治疗与内皮细胞增殖相关的病理生理条件和抑制血管生成的方法。

公开(公告)号：US20090170751A1

公开(公告)日：2009-07-02

申请号：US12148389

申请日：2008-04-18

Applicant: Magnus Hook ,  Sabitha Prabhakaran

Inventor： Magnus Hook ,  Sabitha Prabhakaran

IPC: A61K38/16 ,  C07K14/00 ,  C12N5/02

CPC classification number: C07K14/78 ,  A61K38/00 ,  Y02A50/401

Abstract: Provided herein is a method for inducing formation of a conformationally distinct superfibronectin by contacting plasma fibronectin with BBK32 protein or a BBK32 peptide and the BBK32-induced superfibronectin so formed. Also provided are methods of inhibiting endothelial cell proliferation, of treating pathophysiological conditions associated with endothelial cell proliferation and of inhibiting angiogenesis therein using the BBK32 protein, BBK32 peptide or the BBK32-induced superfibronectin.

Abstract translation: 本文提供通过使血浆纤连蛋白与BBK32蛋白或BBK32肽接触形成的构象不同的超纤连结蛋白和由此形成的BBK32诱导的超纤连结蛋白的方法。 还提供了使用BBK32蛋白，BBK32肽或BBK32诱导的超纤连蛋白来抑制内皮细胞增殖，治疗与内皮细胞增殖相关的病理生理条件和抑制血管生成的方法。