公开(公告)号：US20220133665A1

公开(公告)日：2022-05-05

申请号：US17433755

申请日：2020-02-28

Applicant: MORINAGA MILK INDUSTRY CO., LTD. ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  THE KITASATO INSTITUTE

Inventor： Kanetada Shimizu ,  Ro Osawa ,  Keita Nishiyama ,  Nobuhiko Okada ,  Nobuhiro Koyama ,  Takao Mukai ,  Hiroshi Tomoda

IPC: A61K31/192 ,  A61K35/742 ,  A61K35/745 ,  A61P1/00 ,  A23L33/135 ,  A23L2/52 ,  A23K10/18 ,  A23K20/111

Abstract: The object is to provide a method for inducing pili formation in bacterium of genus Bifidobacterium and a method for promoting intestinal colonization of the bacterium. 3-Phenylpropionic acid and/or 3-(4-hydroxyphenyl)propionic acid are an active ingredient of a composition for inducing the pili formation in the bacterium of genus Bifidobacterium and a composition for promoting the intestinal colonization of the bacterium.

公开(公告)号：US20190083549A1

公开(公告)日：2019-03-21

申请号：US16202274

申请日：2018-11-28

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Yodai Kobayashi ,  Tetsuya Kuhara ,  Kanetada Shimizu ,  Takumi Sato

IPC: A61K35/745 ,  A61P25/28 ,  A23L33/135

Abstract: A novel agent useful for improving brain function is provided. The active ingredient in this agent is a Bifidobacterium breve and/or a Bifidobacterium breve-containing cultured material is provided.

公开(公告)号：US20160114024A1

公开(公告)日：2016-04-28

申请号：US14759124

申请日：2014-03-18

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Tomohiro Tanaka ,  Noriyuki Iwabuchi ,  Yohei Sato ,  Kanetada Shimizu ,  Toshitaka Odamaki

IPC: A61K39/145 ,  A23L2/52 ,  A61K35/74

CPC classification number: A61K35/747 ,  A23K10/12 ,  A23K10/16 ,  A23K10/18 ,  A23L2/52 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/63 ,  A61K35/74 ,  A61K39/145 ,  A61K2035/11 ,  A61K2039/523 ,  C12R1/225

Abstract: The Lactobacillus paracasei MCC1849 (NITE BP-01633) strain, which has a high IL-12 production-promoting action, is used as an ingredient of a drug, food or drink, or feed used for promotion of IL-12 production, immunostimulation, antivirus, or the like.

Abstract translation: 使用具有高IL-12产生促进作用的副干酪乳杆菌MCC1849（NITE BP-01633）菌株作为用于促进IL-12产生，免疫刺激， 防病毒等。

公开(公告)号：US20250000917A1

公开(公告)日：2025-01-02

申请号：US18700380

申请日：2022-10-21

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Daisuke Asaoka ,  Toshifumi Okusa ,  Nobuhiro Sato ,  Kazuya Ono ,  Kanetada Shimizu ,  Noriko Katsumata

IPC: A61K35/745 ,  A61P25/28

Abstract: The brain atrophy suppressor contains, as an active ingredient, a culture containing Bifidobacterium breve MCC1274 (FERM BP-11175) for administration to a subject selected from a healthy individual, an individual diagnosed with mild cognitive impairment, an individual assessed as having cognitive decline and a subject at a risk of a neurodegenerative disease.

公开(公告)号：US20210196768A1

公开(公告)日：2021-07-01

申请号：US17204233

申请日：2021-03-17

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Yodai Kobayashi ,  Tetsuya Kuhara ,  Kanetada Shimizu ,  Takumi Sato

IPC: A61K35/745 ,  A23L33/135 ,  A61P25/28 ,  A61P25/18 ,  C12N1/20 ,  A61P25/24

Abstract: A novel agent useful for improving brain function is provided. The active ingredient in this agent is a Bifidobacterium breve and/or a Bifidobacterium breve-containing cultured material is provided.

公开(公告)号：US20210100852A1

公开(公告)日：2021-04-08

申请号：US16498148

申请日：2018-03-23

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Takuma Sakurai ,  Nanami Hashikura ,  Kanetada Shimizu ,  Sachiko Takahashi ,  Ayako Horigome

IPC: A61K35/745 ,  C12N1/20 ,  A23L33/135 ,  A23L33/00 ,  A23C9/123

Abstract: Novel Bifidobacterium bacteria having an opioid peptide decomposition action and a noncollagenous glycoprotein decomposition action are provided. The present invention relates to one or more kinds of Bifidobacterium bacteria selected from the group consisting of Bifidobacterium bifidum MCC1092 (NITE BP-02429), Bifidobacterium bifidum MCC1319 (NITE BP-02431), Bifidobacterium bifidum MCC1868 (NITE BP-02432), Bifidobacterium bifidum MCC1870 (NITE BP-02433), and Bifidobacterium longum subsp. longum MCC1110 (NITE BP-02430), as well as a composition for decomposing an opioid peptide and composition for decomposing a noncollagenous glycoprotein containing the Bifidobacterium bacteria as an active ingredient.

公开(公告)号：US10653730B2

公开(公告)日：2020-05-19

申请号：US16105467

申请日：2018-08-20

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Tomohiro Tanaka ,  Noriyuki Iwabuchi ,  Yohei Sato ,  Kanetada Shimizu ,  Toshitaka Odamaki

IPC: A61K39/02 ,  A61K35/747 ,  C12R1/225 ,  A23L33/135 ,  A23K10/12 ,  A23K10/16 ,  A23K10/18 ,  A23L2/52 ,  A61K35/74 ,  A61K39/145 ,  A61K35/00 ,  A61K39/00

Abstract: A method for prophylaxis or treatment of a disease includes administering an an effective amount of an agent that contains cells of Lactobacillus paracasei MCC1849 (NITE BP-01633) to a subject in need of such prophylaxis or treatment. The disease can be one or more of an inflammatory disease, ulcer, food allergies, bronchial asthma, urticaria, pollinosis, anaphylactic shock or an opportunistic infection.

公开(公告)号：US20170007650A1

公开(公告)日：2017-01-12

申请号：US15261548

申请日：2016-09-09

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Tomohiro Tanaka ,  Noriyuki Iwabuchi ,  Yohei Sato ,  Kanetada Shimizu ,  Toshitaka Odamaki

IPC: A61K35/747 ,  A23L2/52 ,  A23L33/135 ,  A23K10/18

CPC classification number: A61K35/747 ,  A23K10/12 ,  A23K10/16 ,  A23K10/18 ,  A23L2/52 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/63 ,  A61K35/74 ,  A61K39/145 ,  A61K2035/11 ,  A61K2039/523 ,  C12R1/225

Abstract: The Lactobacillus paracasei MCC1849 (NITE BP-01633) strain, which has a high IL-12 production-promoting action, is used as an ingredient of a drug, food or drink, or feed used for promotion of IL-12 production, immunostimulation, antivirus, or the like.

Abstract translation: 使用具有高IL-12产生促进作用的副干酪乳杆菌MCC1849（NITE BP-01633）菌株作为用于促进IL-12产生，免疫刺激， 防病毒等。

公开(公告)号：US20200181654A1

公开(公告)日：2020-06-11

申请号：US16464459

申请日：2017-06-19

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Ruiqing Yao ,  Kanetada Shimizu ,  Toshitaka Odamaki

IPC: C12P7/22 ,  C12N1/20

Abstract: A technique is provided for degrading a resveratrol glycoside, or degrading a resveratrol glycoside and an isoflavone glycoside, to promote the production of an aglycone(s), thereby enhancing the absorption thereof into a living body. A bacterium belonging to the genus Bifidobacterium is used as an active ingredient of an aglycone production promoter which is used for promoting the production of an aglycone(s) from a glycoside(s). The aglycone production promoter is incorporated into a pharmaceutical composition for preventing and/or treating a disease for which an aglycone(s) is/are effective, or into a food or beverage composition for producing an aglycone(s).

公开(公告)号：US20230066928A1

公开(公告)日：2023-03-02

申请号：US18047477

申请日：2022-10-18

Applicant: MORINAGA MILK INDUSTRY CO., LTD.

Inventor： Takuma Sakurai ,  Nanami Hashikura ,  Kanetada Shimizu ,  Sachiko Takahashi ,  Ayako Horigome

IPC: A61K35/745 ,  A23L33/135 ,  A23L33/00 ,  A23C9/123 ,  C12N1/20

Abstract: Novel Bifidobacterium bacteria having an opioid peptide decomposition action and a noncollagenous glycoprotein decomposition action are provided. The present invention relates to one or more kinds of Bifidobacterium bacteria selected from the group consisting of Bifidobacterium bifidum MCC1092 (NITE BP-02429), Bifidobacterium bifidum MCC1319 (NITE BP-02431), Bifidobacterium bifidum MCC1868 (NITE BP-02432), Bifidobacterium bifidum MCC1870 (NITE BP-02433), and Bifidobacterium longum subsp. longum MCC1110 (NITE BP-02430), as well as a composition for decomposing an opioid peptide and composition for decomposing a noncollagenous glycoprotein containing the Bifidobacterium bacteria as an active ingredient.