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公开(公告)号：US10329263B2
公开(公告)日：2019-06-25
申请号：US16016053
申请日：2018-06-22
IPC分类号： C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , A61K31/53 , A61P9/04 , A61P13/12 , C07D403/12 , C07D413/14 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D453/02 , C07D471/04 , C07D471/08 , C07D253/06 , C07D498/08 , C07D498/10 , C07D451/02
摘要： This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein RA is, for example, a group of the following formula (A-1): wherein ring A1 is, for example, a cycloalkyl group which may be substituted, and RB is, for example, a monocyclic cycloalkyl group, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US10717731B2
公开(公告)日：2020-07-21
申请号：US15769844
申请日：2016-10-21
发明人： Ryo Sakakibara , Hideki Ushirogochi , Wataru Sasaki , Yuichi Onda , Minami Yamaguchi , Fumihiko Akahoshi
IPC分类号： C07D403/12 , C07D403/04 , C07D403/10 , C07D417/12 , C07D405/14 , C07D405/04 , C07D405/12 , C07D213/74 , C07D401/04 , C07D401/12 , C07D237/20 , C07D409/12 , C07D413/12 , C07D241/26 , C07D451/04 , C07D453/02 , C07D471/04 , C07D471/08 , C07D498/08 , C07D407/10 , C07D401/14 , C07D241/20
摘要： A compound represented by general formula [I] wherein X represents N or the like, Y represents CH or the like; RA represents a cycloalkyl group which may be substituted or the like, R1 represents an alkyl group or the like, R2 represents an alkyl group which may be substituted or the like, R3 represents a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has an inhibitory activity on aldosterone synthetase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.
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公开(公告)号：US10029993B2
公开(公告)日：2018-07-24
申请号：US15305587
申请日：2015-04-23
IPC分类号： C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , A61K31/53 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61P9/00 , A61P9/04 , A61P9/12 , C07D403/12 , C07D413/14 , A61K31/541 , A61K31/553 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D453/02 , C07D471/04 , C07D471/08 , C07D253/06 , C07D498/08 , C07D498/10 , C07D451/02
摘要： This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein RA is, for example, a group of the following formula (A-1): wherein ring A1 is, for example, a cycloalkyl group which may be substituted, and RB is, for example, a monocyclic cycloalkyl group, or a pharmaceutically acceptable salt thereof.
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