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公开(公告)号：US20190247385A1
公开(公告)日：2019-08-15
申请号：US16329281
申请日：2017-09-05
申请人： METABRAIN RESEARCH
发明人： Sophie N. Raynal , Annick Audet , Valérie Autier , Christine Charon , Jean-Denis Durand , Micheline Kergoat
CPC分类号： A61K31/47 , A61K9/0053 , A61P21/00
摘要： The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.
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公开(公告)号：US11369595B2
公开(公告)日：2022-06-28
申请号：US16329281
申请日：2017-09-05
申请人： METABRAIN RESEARCH
发明人： Sophie N. Raynal , Annick Audet , Valérie Autier , Christine Charon , Jean-Denis Durand , Micheline Kergoat
摘要： The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.
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公开(公告)号：US20150197530A1
公开(公告)日：2015-07-16
申请号：US14415988
申请日：2013-07-16
申请人： METABRAIN RESEARCH
发明人： Franck F. Lepifre , Gersande R. Lena , Valérie Autier , Micheline Kergoat , Lauren R. Faveriel , Christine G. Charon , Sophie N. Raynal , Annick M. Audet
IPC分类号： C07D493/14 , A61K31/381 , A61K45/06 , A61K31/4025 , A61K31/5377 , A61K31/4436 , C07D333/24 , C07D409/06
CPC分类号： C07D493/14 , A61K31/381 , A61K31/4025 , A61K31/4436 , A61K31/5377 , A61K45/06 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07H9/04
摘要： The present invention relates to a thiophene derivative of the following general formula I or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof or to its use as a drug in particular intended for treating and/or preventing diabetes, its complications and/or associated pathologies, advantageously diabetes of type II and hyperglycemia.
摘要翻译： 本发明涉及以下通式I的噻吩衍生物或其对映异构体，非对映异构体，水合物，溶剂化物，互变异构体，外消旋混合物或其药学上可接受的盐，或其用作特别用于治疗和/或预防糖尿病的药物的用途 ，其并发症和/或相关病理学，有利于II型糖尿病和高血糖。
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公开(公告)号：US20150182507A1
公开(公告)日：2015-07-02
申请号：US14415985
申请日：2013-07-16
申请人： METABRAIN RESEARCH
发明人： Franck F. Lepifre , Gersande R. Lena , Valérie Autier , Micheline R. Kergoat , Christine G. Charon , Sophie N. Raynal , Annick M. Audet
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/444 , C07D471/04 , A61K31/155
CPC分类号： A61K31/437 , A61K31/155 , A61K31/444 , A61K31/5377 , C07D471/04
摘要： The present invention relates to imidazopyridine derivatives of the following general formula I: and to their use as a drug, in particular in treating and/or preventing diabetes, its complications and/or associated pathologies.
摘要翻译： 本发明涉及以下通式I的咪唑并吡啶衍生物及其用作药物，特别是治疗和/或预防糖尿病及其并发症和/或相关病理学的用途。
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