公开(公告)号：US06548275B2

公开(公告)日：2003-04-15

申请号：US10125342

申请日：2002-04-19

申请人： M. David Goldenberg

发明人： M. David Goldenberg

IPC分类号： C12P2104

CPC分类号： A61K51/1018 ,  A61K47/68 ,  A61K51/10 ,  A61K2123/00

摘要： A method of targeting a diagnostic or therapeutic agent to a focus of infection comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of the pathogen or of a pathogen-associated antigen accreted at the focus of infection, the antibody conjugate further comprising a bound diagnostic or therapeutic agent for detecting, imaging or treating the infection. Polyspecific composite conjugates enhance the efficacy of the method, which is especially useful for treating infections that are refractory towards systemic chemotherapy.

公开(公告)号：US06319500B1

公开(公告)日：2001-11-20

申请号：US08158782

申请日：1993-12-01

申请人： M. David Goldenberg

发明人： M. David Goldenberg

IPC分类号： A61K39395

CPC分类号： A61K51/1018 ,  A61K47/68 ,  A61K51/10 ,  A61K2123/00

摘要： A method of targeting a diagnostic or therapeutic agent to a focus of infection comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of the pathogen or of a pathogen-associated antigen accreted at the focus of infection, the antibody conjugate further comprising a bound diagnostic or therapeutic agent for detecting, imaging or treating the infection. Polyspecific composite conjugates enhance the efficacy of the method, which is especially useful for treating infections that are refractory towards systemic chemotherapy.

摘要翻译： 将诊断或治疗剂靶向感染焦点的方法包括将经病毒感染的患者胃肠外注射抗体结合物，所述抗体缀合物特异性结合病原体的可接近表位或在感染重点处引起的病原体相关抗原 所述抗体缀合物还包含用于检测，成像或治疗感染的结合的诊断或治疗剂。 多特异性复合缀合物增强了该方法的功效，其特别适用于治疗对全身化疗难治的感染。

公开(公告)号：US5332567A

公开(公告)日：1994-07-26

申请号：US37659

申请日：1993-03-22

申请人： M. David Goldenberg

发明人： M. David Goldenberg

IPC分类号： A61K47/48 ,  A61K51/10 ,  C12P21/04 ,  A61K43/00 ,  A61K39/00 ,  A61K49/00 ,  G01N1/00

CPC分类号： A61K51/1018 ,  A61K47/48369 ,  A61K51/10 ,  A61K2123/00

摘要： A method of targeting a diagnostic or therapeutic agent to a focus of infection comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of the pathogen or of a pathogen-associated antigen accreted at the focus of infection, the antibody conjugate further comprising a bound diagnostic or therapeutic agent for detecting, imaging or treating the infection. Polyspecific composite conjugates enhance the efficacy of the method, which is especially useful for treating infections that are refractory towards systemic chemotherapy.

摘要翻译： 将诊断或治疗剂靶向感染焦点的方法包括将经病毒感染的患者胃肠外注射抗体结合物，所述抗体缀合物特异性结合病原体的可接近表位或在感染重点处引起的病原体相关抗原 所述抗体缀合物还包含用于检测，成像或治疗感染的结合的诊断或治疗剂。 多特异性复合缀合物增强了该方法的功效，其特别适用于治疗对全身化疗难治的感染。

公开(公告)号：US4460561A

公开(公告)日：1984-07-17

申请号：US415876

申请日：1982-09-08

申请人： M. David Goldenberg

发明人： M. David Goldenberg

IPC分类号： A61K38/00 ,  A61K51/10 ,  C07K16/30 ,  A61K43/00 ,  A61K49/00

CPC分类号： A61K51/1048 ,  C07K16/3007 ,  A61K2121/00 ,  A61K2123/00 ,  A61K38/00

摘要： Methods are provided for using radiolabeled antibodies specific to intracellular tumor-associated markers for detection, localization and therapy of tumors. Injectable compositions for use in the methods of the invention are also provided.

摘要翻译： 提供了使用针对细胞内肿瘤相关标志物特异性的放射性标记的检测，定位和治疗肿瘤的方法。 还提供了用于本发明方法的可注射组合物。