公开(公告)号：US20240099585A1

公开(公告)日：2024-03-28

申请号：US18267670

申请日：2021-12-17

Applicant: LightLab Imaging, Inc.

Inventor： Justin Akira Blaber ,  Ajay Gopinath ,  Wei Chiu

IPC: A61B5/00 ,  A61B5/026 ,  A61B5/107

CPC classification number: A61B5/0066 ,  A61B5/0261 ,  A61B5/1076

Abstract: The present disclosure provides systems and methods for determining a mean transit time of a bolus within the blood vessel by passing the bolus through the blood vessel while an intravascular imaging probe is held stationary. The probe may collect a plurality of image frames as the bolus passes the probe. The cross-sectional area of the bolus within the images frames may be determined by segmenting each image frame by thresholding, creating a vessel mask, and creating a contrast mask by applying an element-wise AND operator to the thresholded image and the vessel mask. The cross-sectional area of the bolus for the image frames may be plotted on an area dilution curve. Various fits may be applied to and various points may be identified on the area dilution curve. The various fits and points may be used to determine the mean transit time.

公开(公告)号：US20230054891A1

公开(公告)日：2023-02-23

申请号：US17890672

申请日：2022-08-18

Applicant: LightLab Imaging, Inc.

Inventor： Wei Chiu ,  Shimin Li ,  Ajay Gopinath ,  Jacob Segev ,  Lorina Dascal

IPC: A61B5/02 ,  G16H30/20

Abstract: Systems and methods are disclosed for identifying features of a blood vessel using extravascular and intravascular images in order to estimate a virtual flow reserve (VFR) of the imaged blood vessel. Aspects of the disclosure include using extravascular images to estimate the size of the blood vessel in regions that have not been intravascularly imaged. The VFR estimation may be based on a resistance model that incorporates both the intravascular image data and the estimated blood vessel size. In other aspects, multiangled extravascular images are captured and analyzed in order to identify the size and orientation of branch vessels.