公开(公告)号：US10111859B2

公开(公告)日：2018-10-30

申请号：US15247164

申请日：2016-08-25

申请人： Ligand Pharmaceuticals, Inc.

发明人： Lin Zhi ,  Andrew R. Hudson ,  Keith Marschke ,  Virginia H. Grant ,  Steven L. Roach ,  Yixing Shen ,  Jason C. Pickens ,  Bijan Pedram ,  Cornelius Arjan van Oeveren ,  Lino J. Valdez

IPC分类号： A61K31/404 ,  C07D401/12 ,  C07D403/12 ,  C07D231/46 ,  C07D405/06 ,  C07D209/34 ,  A61K31/41 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/454 ,  A61K45/06 ,  A61N5/10 ,  C12Q1/18 ,  C12Q1/66 ,  C07D231/52

摘要： Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

公开(公告)号：US11413274B2

公开(公告)日：2022-08-16

申请号：US16925926

申请日：2020-07-10

申请人： Ligand Pharmaceuticals, Inc.

发明人： Lin Zhi ,  Keith Marschke ,  Virginia H. Grant ,  Steven L. Roach ,  Yixing Shen ,  Jason C. Pickens ,  Bijan Pedram ,  Cornelis Arjan van Oeveren ,  Lino J. Valdez ,  Andrew R. Hudson

IPC分类号： C07D209/34 ,  A61K31/404 ,  C07D403/12 ,  C07D231/46 ,  C07D405/06 ,  A61K31/41 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/454 ,  A61K45/06 ,  A61N5/10 ,  C07D401/12 ,  C12Q1/18 ,  C12Q1/66 ,  C07D231/52

摘要： Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

公开(公告)号：US10736875B2

公开(公告)日：2020-08-11

申请号：US16126199

申请日：2018-09-10

申请人： Ligand Pharmaceuticals, Inc.

发明人： Lin Zhi ,  Keith Marschke ,  Virginia H. Grant ,  Steven L. Roach ,  Yixing Shen ,  Jason C. Pickens ,  Bijan Pedram ,  Cornelis Arjan van Oeveren ,  Lino J. Valdez ,  Andrew R. Hudson

IPC分类号： C07D209/34 ,  A61K31/404 ,  C07D403/12 ,  C07D231/46 ,  C07D405/06 ,  A61K31/41 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/454 ,  A61K45/06 ,  A61N5/10 ,  C07D401/12 ,  C12Q1/18 ,  C12Q1/66 ,  C07D231/52

摘要： Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

公开(公告)号：US20210046045A1

公开(公告)日：2021-02-18

申请号：US16925926

申请日：2020-07-10

申请人： Ligand Pharmaceuticals, Inc.

发明人： Lin Zhi ,  Keith Marschke ,  Virginia H. Grant ,  Steven L. Roach ,  Yixing Shen ,  Jason C. Pickens ,  Bijan Pedram ,  Cornelis Arjan van Oeveren ,  Lino J. Valdez ,  Andrew R. Hudson

IPC分类号： A61K31/404 ,  C07D403/12 ,  C07D231/46 ,  C07D209/34 ,  C07D405/06 ,  A61K31/41 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/454 ,  A61K45/06 ,  A61N5/10 ,  C07D401/12 ,  C12Q1/18 ,  C12Q1/66 ,  C07D231/52

摘要： Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

公开(公告)号：US20180369197A1

公开(公告)日：2018-12-27

申请号：US16126199

申请日：2018-09-10

申请人： Ligand Pharmaceuticals, Inc.

发明人： Lin Zhi ,  Keith Marschke ,  Virginia H. Grant ,  Steven L. Roach ,  Yixing Shen ,  Jason C. Pickens ,  Bijan Pedram ,  Cornelius Arjan van Oeveren ,  Lino J. Valdez ,  Andrew R. Hudson

IPC分类号： A61K31/404 ,  C07D231/52 ,  C07D403/12 ,  A61N5/10 ,  C07D401/12 ,  C12Q1/18 ,  C12Q1/66 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/454 ,  A61K45/06 ,  C07D209/34 ,  C07D405/06 ,  C07D231/46 ,  A61K31/41

摘要： Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

公开(公告)号：US20160374989A1

公开(公告)日：2016-12-29

申请号：US15247164

申请日：2016-08-25

申请人： Ligand Pharmaceuticals, Inc.

发明人： Lin Zhi ,  Keith Marschke ,  Virginia H. Grant ,  Steven L. Roach ,  Yixing Shen ,  Jason C. Pickens ,  Bijan Pedram ,  Cornelius Arjan van Oeveren ,  Lino J. Valdez ,  Andrew R. Hudson

IPC分类号： A61K31/404 ,  C07D209/34 ,  C07D403/12 ,  A61K31/4152 ,  C07D401/12 ,  A61K31/454 ,  A61K31/4155 ,  C07D231/52 ,  A61K45/06 ,  A61K31/41

CPC分类号： A61K31/404 ,  A61K31/41 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/454 ,  A61K45/06 ,  A61N5/10 ,  C07D209/34 ,  C07D231/46 ,  C07D231/52 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C12Q1/18 ,  C12Q1/66

摘要： Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

摘要翻译： 一些实施方案包括使用或鉴定调节粒细胞集落刺激因子受体（GCFR）的活性的化合物的组合物和方法。 一些实施方案包括使用化合物来治疗某些疾病，例如造血或神经障碍。