公开(公告)号：US20220227792A1

公开(公告)日：2022-07-21

申请号：US17616559

申请日：2020-06-15

Applicant: LOYOLA UNIVERSITY OF CHICAGO

Inventor： Daniel Paul Becker ,  Sebastian Flieger ,  Isaac Schwarz

IPC: C07F5/02 ,  C07D401/12 ,  C07D279/12 ,  C07D213/42 ,  C07D265/30

Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and (II) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.