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公开(公告)号：US07714063B2
公开(公告)日：2010-05-11
申请号：US12264948
申请日：2008-11-05
IPC分类号： A61K47/48 , A61K31/405 , C08G73/06 , C08F6/22 , C07K5/00
摘要： The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides.
摘要翻译： 本发明提供了多相固相合成的组合物和方法。 特别地，本发明提供了用于制备用于合成多肽的固体支持物的固体支持物和方法。
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2.发明授权公开(公告)号：US08022181B2
公开(公告)日：2011-09-20
申请号：US12298917
申请日：2007-04-18
IPC分类号： C07K1/04
摘要： The present invention provides a composition and a method for cleaving a peptide from a solid support resin. Hydrochloric acid in an organic water miscible solvent is used to cleave the peptide-resin attachment. Optionally, trifluoroethanol or hexafluoroisopropanol may be added to the cleavage composition to improve results. When using the present cleavage composition, an evaporation or other step to remove carboxylic byproducts is not necessary following the cleavage reaction. After the resin is filtered out of the cleavage mixture, the peptide may be immediately precipitated with water.
摘要翻译： 本发明提供了从固体支持树脂切割肽的组合物和方法。 使用有机水混溶性溶剂中的盐酸切割肽 - 树脂附着物。 任选地，可以向切割组合物中加入三氟乙醇或六氟异丙醇以改善结果。 当使用本发明的切割组合物时，在切割反应之后不需要蒸发或其它除去羧酸副产物的步骤。 将树脂从裂解混合物中过滤出后，可立即用水沉淀该肽。
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3.发明申请公开(公告)号：US20090221791A1
公开(公告)日：2009-09-03
申请号：US12298917
申请日：2007-04-18
摘要： The present invention provides a composition and a method for cleaving a peptide from a solid support resin. Hydrochloric acid in an organic water miscible solvent is used to cleave the peptide-resin attachment. Optionally, trifluoroethanol or hexafluoroisopropanol may be added to the cleavage composition to improve results. When using the present cleavage composition, an evaporation or other step to remove carboxylic byproducts is not necessary following the cleavage reaction. After the resin is filtered out of the cleavage mixture, the peptide may be immediately precipitated with water.
摘要翻译： 本发明提供了从固体支持树脂切割肽的组合物和方法。 使用有机水混溶性溶剂中的盐酸切割肽 - 树脂附着物。 任选地，可以向切割组合物中加入三氟乙醇或六氟异丙醇以改善结果。 当使用本发明的切割组合物时，在切割反应之后不需要蒸发或其它除去羧酸副产物的步骤。 将树脂从裂解混合物中过滤出后，可立即用水沉淀该肽。
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