公开(公告)号：US20140370079A1

公开(公告)日：2014-12-18

申请号：US14271117

申请日：2014-05-06

Applicant: Korea Advanced Institute of Science and Technology (KAIST)

Inventor： Gou Young KOH ,  Chan Kim ,  Hanseul Yang ,  Won Do Heo ,  Injune Kim ,  Sangyong Jon ,  Akiyoshi Uemura

IPC: C12N15/113 ,  A61K31/661 ,  A61K33/24 ,  A61K45/06

CPC classification number: C12N15/1137 ,  A61K9/1271 ,  A61K31/661 ,  A61K31/7088 ,  A61K33/24 ,  A61K45/06 ,  C12N2310/14 ,  C12N2320/31 ,  C12Y306/05 ,  A61K2300/00

Abstract: The present application describes a method of inhibiting tumor growth including contacting the tumor with a compound that inhibits activity of RhoJ protein.

Abstract translation: 本申请描述了抑制肿瘤生长的方法，包括使肿瘤与抑制RhoJ蛋白活性的化合物接触。

公开(公告)号：US09777261B2

公开(公告)日：2017-10-03

申请号：US14740158

申请日：2015-06-15

Applicant: Korea Advanced Institute of Science and Technology (KAIST)

Inventor： Ho Min Kim ,  Jung-Eun Lee ,  Chan Kim ,  Gou Young Koh ,  Gyun Min Lee

IPC: A61K38/16 ,  A61K38/17 ,  C12N9/12 ,  C07K14/71 ,  C07K16/00 ,  A61K33/24 ,  A61K38/45 ,  A61K39/395 ,  A61K38/00 ,  A61K48/00 ,  A61K39/00

CPC classification number: C12N9/12 ,  A61K33/24 ,  A61K38/00 ,  A61K38/45 ,  A61K39/395 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/00 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/70 ,  C07K2319/91 ,  C12Y207/10001

Abstract: The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and placenta growth factor (PIGF) polypeptide comprising a nucleotide sequence encoding a VEGFR1 component.

公开(公告)号：US20160032259A1

公开(公告)日：2016-02-04

申请号：US14740158

申请日：2015-06-15

Applicant: Korea Advanced Institute of Science and Technology (KAIST)

Inventor： Ho Min KIM ,  Jung-Eun Lee ,  Chan Kim ,  Gou Young Koh ,  Gyun Min Lee

IPC: C12N9/12 ,  A61K38/45 ,  A61K39/395 ,  A61K33/24 ,  C07K16/00

CPC classification number: C12N9/12 ,  A61K33/24 ,  A61K38/00 ,  A61K38/45 ,  A61K39/395 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/00 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/70 ,  C07K2319/91 ,  C12Y207/10001

Abstract: The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and placenta growth factor (PIGF) polypeptide comprising a nucleotide sequence encoding a VEGFR1 component.

Abstract translation: 本申请描述了编码能够同时结合VEGF多肽和胎盘生长因子（PIGF）多肽的分离的核酸分子，其包含编码VEGFR1组分的核苷酸序列。