公开(公告)号：US20200376138A1

公开(公告)日：2020-12-03

申请号：US16892172

申请日：2020-06-03

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Sangyong Jon ,  Jin Yong Kim ,  Hyeongseop Keum ,  Jinjoo Kim

IPC: A61K47/69 ,  A61K47/64 ,  A61K47/54 ,  A61K9/00 ,  A61P29/00 ,  A61K38/17 ,  A61P11/00

Abstract: The present invention relates to a lipid nanoparticle complex comprising an aptide fused with a cell penetrating material and a use thereof. Particularly, the lipid nanoparticle complex according to the present invention contains long-chain and short-chain phospholipids, and comprises an aptide fused with a cell-penetrating material. In particular, when the long-chain and short-chain phospholipids are included in a specific molar ratio, the lipid nanoparticle complex exhibits a discoid structure. In addition, when the lipid nanoparticle complex comprises the aptide for STAT protein as an aptide, it has superior cell or skin cell permeability, delivers the aptide to the dermal layer to show treatment effect on psoriasis without side effects, inhibits the expression of fibrosis-related genes increased by TGF-β, and attenuates symptoms of pulmonary fibrosis in in vivo model. Thus, the lipid nanoparticle complex according to the present invention can be effectively used as a carrier for various aptides.