COMPOSITION, KIT, AND METHOD FOR DIAGNOSING ADHD RISK
    1.
    发明申请
    COMPOSITION, KIT, AND METHOD FOR DIAGNOSING ADHD RISK 审中-公开
    用于诊断ADHD风险的组合物,套件和方法

    公开(公告)号:US20150322526A1

    公开(公告)日:2015-11-12

    申请号:US14795188

    申请日:2015-07-09

    CPC classification number: C12Q1/6883 C12Q2600/156 G01N21/76

    Abstract: Provided is a method for predicting the risk of attention deficit hyperactivity disorder (ADHD). The method comprises: 1) isolating a nucleic acid species from a biological species derived from a subject; 2) identifying the nucleotide of rs550818 single nucleotide polymorphism (SNP) in the GIT1 gene, which is the 24926101st nucleotide residue on human chromosome 17, from the nucleic acid isolated from stage 1); and 3) determining the risk of ADHD to be high when the genotype of rs550818 SNP that is identified in stage 2) carries T nucleotide; wherein the composition comprising a primer pair for amplifying a rs550818 single nucleotide polymorphism (SNP), wherein the primer pair comprises a primer having a sequence of SEQ ID NO:18 and a primer having a sequence of SEQ ID NO: 45.

    Abstract translation: 提供了一种预测注意缺陷多动障碍(ADHD)风险的方法。 该方法包括:1)从衍生自受试者的生物物种中分离核酸物种; 2)从分离自第1阶段的核酸识别GIT1基因中rs550818单核苷酸多态性(SNP)的核苷酸,其为人染色体17上的24926101个核苷酸残基; 和3)当在阶段2中鉴定的rs550818 SNP的基因型携带T核苷酸时,确定ADHD的风险高; 其中所述组合物包含用于扩增rs550818单核苷酸多态性(SNP)的引物对,其中所述引物对包含具有SEQ ID NO:18的序列的引物和具有SEQ ID NO:45的序列的引物。

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