公开(公告)号：US20220268672A1

公开(公告)日：2022-08-25

申请号：US17675808

申请日：2022-02-18

Applicant: Korea Advanced Institute Of Science And Technology

Inventor： Jae-Byum CHANG ,  In CHO ,  Chan E. PARK ,  Jueun SIM ,  Young-Gyu YOON

IPC: G01N1/30 ,  G06T7/33

Abstract: Disclosed are three-dimensional image registration via dense staining and a super-resolution multiplexed imaging method using the same. The three-dimensional image registration includes: placing at least one fiducial marker in an internal structure of a living tissue via dense staining; obtaining a plurality of images by repeatedly imaging the living tissue while replacing a fluorescent label attached to at least one target molecule within the living tissue where the fiducial marker is placed; and registering the images using the fiducial marker as a reference to obtain a final image of the target molecule.