公开(公告)号：US11021478B2

公开(公告)日：2021-06-01

申请号：US16611838

申请日：2018-05-08

申请人： Kind Pharmaceutical

发明人： Dong Liu ,  Dongdong Chen ,  Biao Deng ,  Xiangyun Tu ,  Zinan Fang ,  Haohao Wu ,  Danyan Gu

IPC分类号： C07D471/04 ,  C07D491/20 ,  A61P7/00

摘要： This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.

公开(公告)号：US11655249B2

公开(公告)日：2023-05-23

申请号：US17239362

申请日：2021-04-23

申请人： Kind Pharmaceutical

发明人： Dong Liu ,  Dongdong Chen ,  Biao Deng ,  Xiangyun Tu ,  Zinan Fang ,  Haohao Wu ,  Danyan Gu

IPC分类号： C07D471/04 ,  A61P7/00 ,  C07D491/20

CPC分类号： C07D471/04 ,  A61P7/00 ,  C07D491/20

摘要： This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.

公开(公告)号：US11945817B2

公开(公告)日：2024-04-02

申请号：US18132913

申请日：2023-04-10

申请人： Kind Pharmaceutical

发明人： Dong Liu ,  Dongdong Chen ,  Biao Deng ,  Xiangyun Tu ,  Zinan Fang ,  Haohao Wu ,  Danyan Gu

IPC分类号： C07D471/04 ,  A61P7/00 ,  C07D491/20

CPC分类号： C07D471/04 ,  A61P7/00 ,  C07D491/20

摘要： This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.

公开(公告)号：US11970495B2

公开(公告)日：2024-04-30

申请号：US18132907

申请日：2023-04-10

申请人： Kind Pharmaceutical

发明人： Dong Liu ,  Dongdong Chen ,  Biao Deng ,  Xiangyun Tu ,  Zinan Fang ,  Haohao Wu ,  Danyan Gu

IPC分类号： C07D471/04 ,  A61P7/00 ,  C07D491/20

CPC分类号： C07D471/04 ,  A61P7/00 ,  C07D491/20

摘要： This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.

公开(公告)号：US20210253570A1

公开(公告)日：2021-08-19

申请号：US17239362

申请日：2021-04-23

申请人： Kind Pharmaceutical

发明人： Dong LIU ,  Dongdong Chen ,  Biao Deng ,  Xiangyun Tu ,  Zinan Fang ,  Haohao Wu ,  Danyan Gu

IPC分类号： C07D471/04 ,  A61P7/00 ,  C07D491/20

摘要： This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.