公开(公告)号：US20240228583A1

公开(公告)日：2024-07-11

申请号：US18289037

申请日：2022-05-03

Applicant: Keros Therapeutics, Inc.

Inventor： Jasbir S. SEEHRA ,  Jennifer LACHEY ,  Claire TSENG ,  Elissa FURUTANI ,  Christopher R. ROVALDI

IPC: C07K14/71 ,  A61K47/68 ,  A61P9/12 ,  A61P13/12 ,  A61P19/00 ,  A61P21/00 ,  C07K14/78

CPC classification number: C07K14/71 ,  A61K47/68 ,  A61P9/12 ,  A61P13/12 ,  A61P19/00 ,  A61P21/00 ,  C07K14/78 ,  C07K2319/30 ,  C07K2319/70

Abstract: The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness or atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, pulmonary hypertension, and/or diseases and conditions that can be treated with erythropoietin or an erythropoiesis-stimulating agent.

公开(公告)号：US20230079602A1

公开(公告)日：2023-03-16

申请号：US17945299

申请日：2022-09-15

Applicant: Keros Therapeutics, Inc.

Inventor： Jasbir S. SEEHRA ,  Jennifer LACHEY ,  Claire TSENG ,  Jason O'NEILL ,  Henning THØGERSEN ,  Elissa FURUTANI

IPC: C07K14/71 ,  A61P21/00 ,  A61P19/08 ,  A61P7/06 ,  A61P11/00 ,  A61P3/04 ,  A61P7/04 ,  A61P7/00

Abstract: The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and/or pulmonary hypertension.