公开(公告)号：US20240358797A1

公开(公告)日：2024-10-31

申请号：US18656385

申请日：2024-05-06

Applicant: Kernal Biologics, Inc.

Inventor： Monia DRAGHI ,  Rudy CHRISTMAS ,  Cafer OZDEMIR ,  Burak YILMAZ ,  Yusuf ERKUL ,  Manfred KRAUS

IPC: A61K38/21 ,  A61K9/51 ,  A61K38/17 ,  A61K38/20 ,  A61K48/00 ,  A61P35/00

CPC classification number: A61K38/212 ,  A61K9/5123 ,  A61K38/1709 ,  A61K38/2013 ,  A61K38/208 ,  A61K38/2086 ,  A61K48/005 ,  A61P35/00

Abstract: The present disclosure provides technologies for achieving treatment of cancer. The present disclosure provides methods and compositions for the treatment of cancer using oncoselective construct designs that can be used to encode payloads of high therapeutic interest. The present disclosure recognizes that treatment of individuals suffering from cancer with engineered nucleic acids of the disclosure in combination with immune checkpoint therapy provides unique advantages.