公开(公告)号：US20120028962A1

公开(公告)日：2012-02-02

申请号：US13201536

申请日：2010-02-17

申请人： Kentaro Rikimaru ,  Hiroshi Imoto ,  Masahiro Kamaura

发明人： Kentaro Rikimaru ,  Hiroshi Imoto ,  Masahiro Kamaura

IPC分类号： A61K31/55 ,  C07D211/32 ,  C07D403/14 ,  A61P3/04 ,  A61K31/519 ,  A61K31/454 ,  A61K31/506 ,  A61P3/10 ,  C07D487/04 ,  C07D413/14

CPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

摘要： A compound represented by the following formula or a salt thereof, which has an GPR119 agonist action, is useful for the prophylaxis or treatment of diabetes, obesity and the like, and shows superior efficacy: wherein P: substituted 6-membered aromatic ring, Q: (substituted) 6-membered aromatic ring, CR4aR4b, NR4c, O, S, SO or SO2 {R4a-4c: H etc.}, L1: (substituted) C1-5 alkylene, L2: a bond or (substituted) C1-3 alkylene, L3-4: (substituted) C1-3 alkylene, R1: H, X, CN, (substituted) hydrocarbon, (substituted) heterocycle or (substituted) OH, or (substituted) 4- to 8-membered (heterocyclic) ring together with A1, R2: H, CN, (substituted) hydrocarbon, and R3a: —COSRA1, (substituted) 5- or 6-membered aromatic ring {RA1: (substituted) hydrocarbon or (substituted) heterocycle}.

摘要翻译： 由下式表示的化合物或其盐具有GPR119激动剂作用，可用于预防或治疗糖尿病，肥胖症等，并且显示出优异的疗效：其中P：取代的6元芳环Q ：（取代的）6元芳环，CR4aR4b，NR4c，O，S，SO或SO2（R4a-4c：H等），L1：（取代的）C1-5亚烷基，L2： -3亚烷基，L3-4：（取代的）C1-3亚烷基，R1：H，X，CN，（取代的）烃，（取代的）杂环或（取代的）OH或（取代的）4-至8-元 杂环）与A1，R2：H，CN，（取代的）烃和R3a：-COSRA1，（取代的）5元或6元芳环{RA1：（取代的）烃或（取代的）杂环）一起。

公开(公告)号：US08410089B2

公开(公告)日：2013-04-02

申请号：US13201536

申请日：2010-02-17

申请人： Kentaro Rikimaru ,  Hiroshi Imoto ,  Masahiro Kamaura

发明人： Kentaro Rikimaru ,  Hiroshi Imoto ,  Masahiro Kamaura

IPC分类号： A01N43/00 ,  A61K31/55

CPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

摘要： A compound represented by the following formula or a salt thereof, which has an GPR119 agonist action, is useful for the prophylaxis or treatment of diabetes, obesity and the like, and shows superior efficacy: wherein P: substituted 6-membered aromatic ring, Q: (substituted) 6-membered aromatic ring, A1: CR4aR4b, NR4c, O, S, SO or SO2 {R4a-4c: H etc.}, L1: (substituted) C1-5 alkylene, L2: a bond or (substituted) C1-3 alkylene, L3-4: (substituted) C1-3 alkylene, R1: H, X, CN, (substituted) hydrocarbon, (substituted) heterocycle or (substituted) OH, or (substituted) 4- to 8-membered (heterocyclic) ring together with A1, R2: H, CN, (substituted) hydrocarbon, and R3a: —COSRA1, (substituted) 5- or 6-membered aromatic ring {RA1: (substituted) hydrocarbon or (substituted) heterocycle}.

摘要翻译： 由下式表示的化合物或其盐具有GPR119激动剂作用，可用于预防或治疗糖尿病，肥胖症等，并且显示出优异的疗效：其中P：取代的6元芳环Q ：（取代的）6元芳环，A1：CR4aR4b，NR4c，O，S，SO或SO2（R4a-4c：H等），L1：（取代的）C1-5亚烷基，L2： ）C 1-3亚烷基，L3-4：（取代的）C1-3亚烷基，R1：H，X，CN，（取代的）烃，（取代的）杂环或（取代的）OH或（取代的） （取代的）烃和R3a：-COSRA1，（取代的）5元或6元芳环{RA1：（取代的）烃或（取代的）杂环} 。