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公开(公告)号：US20120142651A1
公开(公告)日：2012-06-07
申请号：US13370493
申请日：2012-02-10
申请人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
发明人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.
摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。
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2.发明授权公开(公告)号：US07132532B2
公开(公告)日：2006-11-07
申请号：US10862591
申请日：2004-06-07
IPC分类号： C07J17/00
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： The present invention relates to, for example, a compound of formula (VIII) useful in the manufacture of anti-inflammatory androstane derivatives.
摘要翻译： 本发明涉及例如可用于制造消炎雄甾烷衍生物的式（Ⅷ）化合物。
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公开(公告)号：US20100311706A1
公开(公告)日：2010-12-09
申请号：US12858940
申请日：2010-08-18
申请人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
发明人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.
摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。
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公开(公告)号：US07592329B2
公开(公告)日：2009-09-22
申请号：US10503114
申请日：2003-02-04
申请人： Keith Biggadike , Steven John Coote , Andrew Craig , David Malcolm Crowe , Victor Witold Jacewicz , Michael John Millan , Rosalyn Kay Nice , Brian Noga , John Frederick Seager , Andrew Lewis Theophilus
发明人： Keith Biggadike , Steven John Coote , Andrew Craig , David Malcolm Crowe , Victor Witold Jacewicz , Michael John Millan , Rosalyn Kay Nice , Brian Noga , John Frederick Seager , Andrew Lewis Theophilus
摘要： There is provided a crystalline complex comprising a compound of formula (I) in which the crystal lattice is stabilized by the presence of a guest molecule, characterized in that the crystalline complex is of space group P212121 having unit cell dimensions of about 12.5±1.0 §, 15±1.0 §, and 16.2±1.0 § when determined at either 120K or 150K.
摘要翻译： 提供了一种结晶复合物，其包含式（I）化合物，其中晶格通过客体分子的存在而稳定，其特征在于结晶复合物为具有约12.5±1.0的晶胞尺寸的空间群P212121§ ，15±1.0§和16.2±1.0§当在120K或150K下测定时。
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公开(公告)号：US07629335B2
公开(公告)日：2009-12-08
申请号：US11428853
申请日：2006-07-06
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.
摘要翻译： 根据本发明的一个方面，提供式（I）的化合物及其溶剂合物。 还提供含有该化合物的组合物，其制备方法及其在治疗中的用途。
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6.发明授权公开(公告)号：US07144845B2
公开(公告)日：2006-12-05
申请号：US10862792
申请日：2004-06-07
IPC分类号： C07J17/00
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： The present invention relates to, for example, compounds of formula (VI) useful in the manufacture of anti-inflammatory androstane derivatives.
摘要翻译： 本发明涉及例如可用于制造抗炎雄甾烷衍生物的式（VI）化合物。
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7.发明授权公开(公告)号：US07125985B2
公开(公告)日：2006-10-24
申请号：US10862555
申请日：2004-06-07
IPC分类号： C07J17/00
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： The present invention relates to, for example, a compound of formula (X) useful in the manufacture of anti-inflammatory androstane derivatives.
摘要翻译： 本发明涉及例如可用于制造抗炎雄甾烷衍生物的式（X）化合物。
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公开(公告)号：US07101866B2
公开(公告)日：2006-09-05
申请号：US09958050
申请日：2001-08-03
CPC分类号： C07J31/006
摘要： According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.
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