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1.发明申请公开(公告)号：US20130046225A1
公开(公告)日：2013-02-21
申请号：US13394765
申请日：2010-10-07
申请人： Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba , Ako Nose
发明人： Yukihiko Nose , Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba
CPC分类号： A61K31/727 , A61K31/135 , A61M1/14 , A61M1/16 , A61M1/3486 , A61M1/3496 , A61M1/3621 , B01D15/00 , B01J20/00 , B01J20/22 , B01J2220/4825 , B01J2220/4831 , A61K2300/00
摘要： The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
摘要翻译： 本发明提供了一种通过使他与生物相容性生物材料进行约1小时的分离程序来在人体内产生天然的免疫活性状态的方法。 为了安全地控制由该程序引起的免疫休克，将该人全身麻醉约6小时，包括分离时间，此后至少另外5小时。 这种免疫激活可用于治疗恶性肿瘤和与免疫抑制相关的疾病，如艾滋病。 本发明还提供使用含有血液灌注过滤器的生物相容性材料用于治疗恶性肿瘤和感染性疾病的单采血液柱。
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2.发明申请CRYOAGGREGATE FILTRATION FOR THE TREATMENT OF CARDIOMYOPATHY AND OTHER AUTOIMMUNE DISEASES 审中-公开用于治疗心脏病和其他自身免疫性疾病的血液滤过公开(公告)号：US20110197628A1
公开(公告)日：2011-08-18
申请号：US12864290
申请日：2009-01-26
IPC分类号： B01D9/02
CPC分类号： A61M1/3472 , A61M1/3482
摘要： Various embodiments of the present invention disclose processes and systems for the off-line in-vitro purification of plasma harvested from a patient. In an embodiment of a process, in a first step cellular components are capable of being eliminated by membrane plasma separation at temperatures sufficiently high to avoid formation of a cryoaggregates, and in a second step the resulting plasma solution is cooled to a temperature that allows the formation of cryoaggragated molecules, but no formation of a cryogel.
摘要翻译： 本发明的各种实施方案公开了从患者收获的血浆的离线体外纯化的方法和系统。 在方法的一个实施方案中，在第一步中，细胞组分能够通过在足够高的温度下通过膜血浆分离来消除，以避免形成低聚集体，并且在第二步骤中，将得到的血浆溶液冷却至允许 形成冷冻分子，但没有形成冷冻凝胶。
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