公开(公告)号：US08677249B2

公开(公告)日：2014-03-18

申请号：US12331875

申请日：2008-12-10

申请人： Karl Büttner ,  Erich E. Orenchuk ,  Rakesh Shukla

发明人： Karl Büttner ,  Erich E. Orenchuk ,  Rakesh Shukla

IPC分类号： G06F17/00

CPC分类号： G06F17/2247 ,  G06F3/0481 ,  G06F3/0485 ,  G06F9/451 ,  G06F17/241

摘要： A system for providing a graphical interface to a user includes a server platform and an operating system and application software running thereon. The system includes a client device capable of running a standard web browser that accesses the software application on the server platform for displaying information to the user in a display area on the client device. The web browser displays the information without requiring additional software to be installed, downloaded or run on the client device, and without requiring a scripting language to be enabled in the web browser on the client. The application software facilitates user manipulation of unstructured data in the display area for detailed inspection, and facilitates the user selectively causing to display annotations within the display area. The application software facilitates the user inserting annotations within the display area, thereby causing an action to occur in this system or an external system.

摘要翻译： 用于向用户提供图形界面的系统包括服务器平台以及在其上运行的操作系统和应用软件。 该系统包括能够运行标准Web浏览器的客户端设备，其访问服务器平台上的软件应用，以在客户端设备上的显示区域中向用户显示信息。 Web浏览器显示信息，而不需要在客户端设备上安装，下载或运行其他软件，并且不需要在客户端的Web浏览器中启用脚本语言。 应用软件便于用户对显示区域中的非结构化数据进行操作以进行详细检查，并且便于用户选择性地在显示区域内显示注释。 应用软件便于用户在显示区域内插入注释，从而在该系统或外部系统中引起动作。

公开(公告)号：US07478332B2

公开(公告)日：2009-01-13

申请号：US11805857

申请日：2007-05-24

申请人： Karl Büttner ,  Erich E. Orenchuk ,  Rakesh Shukla

发明人： Karl Büttner ,  Erich E. Orenchuk ,  Rakesh Shukla

IPC分类号： G06F17/00

CPC分类号： G06F17/2247 ,  G06F3/0481 ,  G06F3/0485 ,  G06F9/451 ,  G06F17/241

摘要： A system for providing a graphical interface to a user includes a server platform and an operating system and application software running thereon. The system further includes a client device capable of running a standard web browser that accesses the software application on the server platform for displaying information to the user in a display area on the client device. The standard web browser displays the information without requiring additional software to be installed or downloaded or run on the client device, and without requiring a scripting language to be enabled in the web browser on the client device. The application software facilitates manipulation by the user of unstructured data in the display area for detailed inspection, and also facilitates the user selectively causing to display annotations within the display area. The application software facilitates the user inserting one or more annotations within the display area, thereby causing an action to occur in either this system or an external system.

摘要翻译： 用于向用户提供图形界面的系统包括服务器平台以及在其上运行的操作系统和应用软件。 该系统还包括能够运行标准web浏览器的客户端设备，其访问服务器平台上的软件应用，以在客户端设备上的显示区域中向用户显示信息。 标准Web浏览器显示信息，而不需要在客户端设备上安装或下载或运行其他软件，并且不需要在客户端设备的Web浏览器中启用脚本语言。 应用软件便于用户对显示区域中的非结构化数据进行操作以进行详细检查，并且还有助于用户选择性地在显示区域内显示注释。 应用软件便于用户在显示区域内插入一个或多个注释，从而导致在该系统或外部系统中发生动作。

公开(公告)号：US08946261B2

公开(公告)日：2015-02-03

申请号：US13984998

申请日：2012-01-24

申请人： Kuldeep Kumar Roy ,  Santoshkumar Tota ,  Chandishwar Nath ,  Rakesh Shukla ,  Anil Kumar Saxena

发明人： Kuldeep Kumar Roy ,  Santoshkumar Tota ,  Chandishwar Nath ,  Rakesh Shukla ,  Anil Kumar Saxena

IPC分类号： C07D215/20 ,  A61K31/04

CPC分类号： C07D215/20

摘要： The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of neurodegenerative or Alzheimer's disease, or senile dementia, or memory disturbances, and more particularly to the prevention, treatment and amelioration of Alzheimer's disease with the novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, which act as inhibitors of central cholinesterase enzymes, particularly acetylcholinesterase (AChE) following the indirect cholinomimetic pathway. The present invention particularly relates to compounds of formula A: Formula A wherein R1=alkyl, aryl, substituted aryl; R2=H, methyl; R3=H, alkyl, alkenyl, alkynyl, aralkyl, substituted aralkyl, aryl, heteroaryl.

摘要翻译： 本发明涉及新的取代的1,2,3,4-四氢喹啉-7-基氨基甲酸酯，其制备和用作治疗剂，特别是用于预防或治疗神经变性或阿尔茨海默病，老年痴呆或记忆障碍 更具体地涉及用新型取代的1,2,3,4-四氢喹啉-7-基氨基甲酸酯预防，治疗和改善阿尔茨海默氏病，其作为中枢胆碱酯酶的抑制剂，特别是乙酰胆碱酯酶（AChE），其是间接的 胆碱途径 本发明特别涉及式A的化合物：式A其中R1 =烷基，芳基，取代的芳基; R2 = H，甲基; R3 = H，烷基，烯基，炔基，芳烷基，取代的芳烷基，芳基，杂芳基。

公开(公告)号：US20080005678A1

公开(公告)日：2008-01-03

申请号：US11805857

申请日：2007-05-24

申请人： Karl Buttner ,  Erich Orenchuk ,  Rakesh Shukla

发明人： Karl Buttner ,  Erich Orenchuk ,  Rakesh Shukla

IPC分类号： G06F3/00

CPC分类号： G06F17/2247 ,  G06F3/0481 ,  G06F3/0485 ,  G06F9/451 ,  G06F17/241

摘要： A system for providing a graphical interface to a user includes a server platform and an operating system and application software running thereon. The system further includes a client device capable of running a standard web browser that accesses the software application on the server platform for displaying information to the user in a display area on the client device. The standard web browser displays the information without requiring additional software to be installed or downloaded or run on the client device, and without requiring a scripting language to be enabled in the web browser on the client device. The application software facilitates manipulation by the user of unstructured data in the display area for detailed inspection, and also facilitates the user selectively causing to display annotations within the display area. The application software facilitates the user inserting one or more annotations within the display area, thereby causing an action to occur in either this system or an external system

摘要翻译： 用于向用户提供图形界面的系统包括服务器平台以及在其上运行的操作系统和应用软件。 该系统还包括能够运行标准web浏览器的客户端设备，其访问服务器平台上的软件应用，以在客户端设备上的显示区域中向用户显示信息。 标准Web浏览器显示信息，而不需要在客户端设备上安装或下载或运行其他软件，并且不需要在客户端设备的Web浏览器中启用脚本语言。 应用软件便于用户对显示区域中的非结构化数据进行操作以进行详细检查，并且还有助于用户选择性地在显示区域内显示注释。 应用软件便于用户在显示区域内插入一个或多个注释，从而导致在该系统或外部系统中发生动作

公开(公告)号：US20130324573A1

公开(公告)日：2013-12-05

申请号：US13984998

申请日：2012-01-24

申请人： Kuldeep Kumar Roy ,  Santoshkumar Tota ,  Chandishwar Nath ,  Rakesh Shukla ,  Anil Kumar Saxena

发明人： Kuldeep Kumar Roy ,  Santoshkumar Tota ,  Chandishwar Nath ,  Rakesh Shukla ,  Anil Kumar Saxena

IPC分类号： C07D215/20

CPC分类号： C07D215/20

摘要： The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of neurodegenerative or Alzheimer's disease, or senile dementia, or memory disturbances, and more particularly to the prevention, treatment and amelioration of Alzheimer's disease with the novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, which act as inhibitors of central cholinesterase enzymes, particularly acetylcholinesterase (AChE) following the indirect cholinomimetic pathway. The present invention particularly relates to compounds of formula A: Formula A wherein R1=alkyl, aryl, substituted aryl; R2═H, methyl; R3═H, alkyl, alkenyl, alkynyl, aralkyl, substituted aralkyl, aryl, heteroaryl.

摘要翻译： 本发明涉及新的取代的1,2,3,4-四氢喹啉-7-基氨基甲酸酯，其制备和用作治疗剂，特别是用于预防或治疗神经变性或阿尔茨海默病，老年痴呆或记忆障碍 更具体地涉及用新型取代的1,2,3,4-四氢喹啉-7-基氨基甲酸酯预防，治疗和改善阿尔茨海默氏病，其作为中枢胆碱酯酶的抑制剂，特别是乙酰胆碱酯酶（AChE），其是间接的 胆碱途径 本发明特别涉及式A的化合物：式A其中R1 =烷基，芳基，取代的芳基; R2 = H，甲基; R 3 = H，烷基，烯基，炔基，芳烷基，取代的芳烷基，芳基，杂芳基。