公开(公告)号：US20180016346A1

公开(公告)日：2018-01-18

申请号：US15541872

申请日：2016-01-08

申请人： KYOWA HAKKO KIRIN CO., LTD

发明人： Nobuaki TAKAHASHI ,  Makoto NAKAYAMA ,  Sayaka TAKAGI

IPC分类号： C07K16/30 ,  C07K16/28 ,  G01N33/574

CPC分类号： C07K16/3069 ,  A61K39/395 ,  C07K16/28 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C12N5/10 ,  C12N15/09 ,  G01N33/57492 ,  G01N2333/70578 ,  G01N2333/948

摘要： The present invention is related to a bispecific antibody or an antibody fragment thereof comprising an antigen binding domain that binds to a TRAILR2, and an antigen binding domain that binds to a PSMA; a nucleic acid comprising a nucleotide sequence that encodes the antibody or the antibody fragment thereof; a recombinant vector comprising the nucleic acid; a transformant comprising the recombinant vector; a method for producing the bispecific antibody or the antibody fragment thereof by using the transformant; and a reagent for detection or measurement, a diagnostic agent, and a therapeutic agent, each of which comprises the bispecific antibody or the antibody fragment thereof.