公开(公告)号：US20170304199A1

公开(公告)日：2017-10-26

申请号：US15514155

申请日：2015-09-25

Applicant: KOWA COMPANY, LTD.

Inventor： Hiroshi ODA ,  Yuuki SUZUKI

IPC: A61K9/08 ,  C08K5/3475 ,  B65D81/30 ,  A61K31/551 ,  C08K3/22 ,  A61J1/14

CPC classification number: A61K9/08 ,  A61J1/1468 ,  A61K31/551 ,  A61P27/02 ,  A61P27/06 ,  B65D81/30 ,  C08K3/22 ,  C08K5/3475 ,  C08K2003/2241

Abstract: A technique is provided for improving the stability of a halogenated isoquinoline derivative with respect to light in an aqueous composition. A pharmaceutical preparation obtained by storing an aqueous composition comprising a compound represented by Formula (1): wherein X represents a halogen atom,or a salt thereof, or a solvate of the compound or the salt thereof, in a package that blocks a ray with a wavelength of 300 to 335 nm.

公开(公告)号：US20170367977A1

公开(公告)日：2017-12-28

申请号：US15535185

申请日：2015-12-11

Applicant: KOWA COMPANY, LTD.

Inventor： Yuuki SUZUKI ,  Isamu SAWAI ,  Hiroshi ODA

IPC: A61K9/08 ,  A61K47/32 ,  A61K47/22 ,  A61K31/352 ,  A61K31/18 ,  A61K31/5377 ,  A61K31/4725 ,  A61K31/435 ,  A61K31/551 ,  A61K45/06

CPC classification number: A61K9/08 ,  A61K9/0048 ,  A61K31/18 ,  A61K31/352 ,  A61K31/353 ,  A61K31/435 ,  A61K31/4704 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  A61K47/22 ,  A61K47/32 ,  A61K2300/00

Abstract: A technique is provided for reducing the discoloration of an aqueous composition containing a halogenated isoquinoline derivative during high-temperature preservation. An aqueous composition comprising a compound represented by Formula (1): wherein X represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, and a β blocker.

公开(公告)号：US20240216272A1

公开(公告)日：2024-07-04

申请号：US18608109

申请日：2024-03-18

Applicant: KOWA COMPANY, LTD.

Inventor： Hiroshi ODA ,  Yuuki SUZUKI

IPC: A61K9/08 ,  A61J1/14 ,  A61K31/551 ,  A61P27/02 ,  A61P27/06 ,  B65D81/30 ,  C08K3/22 ,  C08K5/3475

CPC classification number: A61K9/08 ,  A61J1/1468 ,  A61K31/551 ,  A61P27/02 ,  A61P27/06 ,  B65D81/30 ,  C08K3/22 ,  C08K5/3475 ,  C08K2003/2241

Abstract: A technique is provided for improving the stability of a halogenated isoquinoline derivative with respect to light in an aqueous composition. A pharmaceutical preparation obtained by storing an aqueous composition comprising a compound represented by Formula (1):






wherein X represents a halogen atom,
or a salt thereof, or a solvate of the compound or the salt thereof, in a package that blocks a ray with a wavelength of 300 to 335 nm.