公开(公告)号：US20230043898A1

公开(公告)日：2023-02-09

申请号：US17936657

申请日：2022-09-29

Applicant: KOREA INSTITUTE OF CERAMIC ENGINEERING AND TECHNOLOGY

Inventor： Sung Hyun KIM ,  Hee Sun PARK

IPC: C12N15/62 ,  C07K1/22 ,  C07K14/47 ,  C07K16/00 ,  C07K19/00 ,  C12N15/70

Abstract: The present disclosure relates to a fusion protein of Z-domain and calsequestrin having improved reactivity, stability, and antibody recovery, and a method of isolating and purifying antibodies using the same. Specifically, the present disclosure relates to: a nucleic acid encoding a fusion protein of Z-domain and calsequestrin having improved reactivity, stability, and antibody recovery; a recombinant expression vector including the nucleic acid; a host cell transformed with the recombinant expression vector; and a method of isolating and purifying antibodies by using the fusion protein of Z-domain and calsequestrin having improved reactivity, stability, antibody recovery, and purity.