Patent search ap:("KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY") AND inv:"Che Lin Kim" Page 1

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发明授权
Cell line which is knock out the bmp receptor genes and a method of producing target proteins using the same 有权

公开(公告)号：US11873326B2

公开(公告)日：2024-01-16

申请号：US16556725

申请日：2019-08-30

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gyun-Min Lee , Che Lin Kim

IPC: C07K14/51 , C12N15/10 , C12N15/113

CPC classification number: C07K14/51 , C12N15/102 , C12N15/1136 , C12N2810/40

Abstract: The present invention relates to a transgenic CHO cell line in which the BMP receptor gene BMPRIA or BMPRII is knocked out. The BMP type I receptor BMPRIA or BMP type II receptor BMPRII gene which plays an important role in intracellular signal transduction in CHO cells is knocked out to prevent the activation of self concentration control pathway and the signal transduction mediated by BMP in CHO cells, so that the productivity of a target protein to be produced can be improved.

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