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    Imidazo[1,5-a]pyrido[4,3-e]pyrazines as CK2 inhibitors
    1.
    发明授权
    Imidazo[1,5-a]pyrido[4,3-e]pyrazines as CK2 inhibitors 有权

    公开(公告)号：US12187726B1

    公开(公告)日：2025-01-07

    申请号：US18434637

    申请日：2024-02-06

    Applicant: KING FAISAL UNIVERSITY

    Inventor： Christophe Tratrat ,  Michelyne Haroun

    IPC: C07D471/14 ,  A61K31/4985 ,  A61P35/00

    Abstract: Novel imidazo[1,5-a]pyrido[4,3-e]pyrazine compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The imidazo[1,5-a]pyrido[4,3-e]pyrazine compounds, identified as CK2 inhibitors, are useful as anticancer and/or antitumor agents, and as agents for treating other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and other types of diseases such as diabetes, viral infection, neurodegenerative diseases.

    Pyrrolo[3,2-c][2,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
    2.
    发明授权
    Pyrrolo[3,2-c][2,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors 有权

    公开(公告)号：US12180209B1

    公开(公告)日：2024-12-31

    申请号：US18586021

    申请日：2024-02-23

    Applicant: KING FAISAL UNIVERSITY

    Inventor： Christophe Tratrat ,  Michelyne Haroun

    IPC: C07D471/14 ,  A61P35/00 ,  A61P35/02

    Abstract: Novel pyrrolo[3,2-c][2,6]naphthyridine-2-carboxylic acid compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The pyrrolo[3,2-c][2,6]naphthyridine-2-carboxylic acid compounds, identified as CK2 inhibitors, are useful as anticancer and/or antitumor agents, and as agents for treating other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and other types of diseases such as diabetes, viral infection, neurodegenerative diseases.

    Pyrimido[1′,6′:1,5]pyrazolo[4,3-b][1,7]naphthyridine compounds as CK2 inhibitors
    3.
    发明授权
    Pyrimido[1′,6′:1,5]pyrazolo[4,3-b][1,7]naphthyridine compounds as CK2 inhibitors 有权

    公开(公告)号：US12173005B1

    公开(公告)日：2024-12-24

    申请号：US18393644

    申请日：2023-12-21

    Applicant: KING FAISAL UNIVERSITY

    Inventor： Christophe Tratrat ,  Michelyne Haroun

    IPC: C07D471/22 ,  A61P35/00

    Abstract: Novel pyrimido[1′,6′:1,5]pyrazolo[4,3-b][1,7]naphthyridine, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The pyrimido[1′,6′:1,5]pyrazolo[4,3-b][1,7]naphthyridine compounds, identified as CK2 inhibitors, are useful as anticancer and/or antitumor agents, and as agents for treating other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and other types of diseases such as diabetes, viral infection, neurodegenerative diseases.

    Pyrazolo[1,5-c]pyrimidine compounds as CK2 inhibitors
    5.
    发明授权
    Pyrazolo[1,5-c]pyrimidine compounds as CK2 inhibitors 有权

    公开(公告)号：US11970499B1

    公开(公告)日：2024-04-30

    申请号：US18395130

    申请日：2023-12-22

    Applicant: KING FAISAL UNIVERSITY

    Inventor： Michelyne Haroun ,  Christophe Tratrat

    IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

    CPC classification number: C07D487/04 ,  A61K31/519 ,  A61P35/00

    Abstract: Novel pyrazolo[1,5-c]pyrimidine compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The pyrazolo[1,5-c]pyrimidine compounds, identified as CK2 inhibitors, are useful as anticancer and/or antitumor agents, and as agents for treating other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and other types of diseases such as diabetes, viral infection, neurodegenerative diseases.

    Pyrazolidinedione derivatives and their use as PPAR-gamma inhibitors
    8.
    发明授权
    Pyrazolidinedione derivatives and their use as PPAR-gamma inhibitors 有权

    公开(公告)号：US11958847B1

    公开(公告)日：2024-04-16

    申请号：US18218982

    申请日：2023-07-06

    Applicant: KING FAISAL UNIVERSITY

    Inventor： Michelyne Haroun ,  Christophe Tratrat

    IPC: C07D417/12 ,  A61P3/10

    CPC classification number: C07D417/12 ,  A61P3/10

    Abstract: The pyrazolidinedione derivatives were found to possess blood glucose lowering properties. These compounds were designed as potential PPAR gamma inhibitors, an essential molecular target for clinically used antidiabetic drugs. Owing to their promising anti-hyperglycemic activity, these derivatives may find useful applications for the treatment and/or prevention of obesity, diabetes type II and I, hyperglycemia and other diseases where PPAR gamma is implicated such as cancer, atherosclerosis and hyperlipidemia.

    Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors
    9.
    发明授权
    Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors 有权

    公开(公告)号：US11952378B1

    公开(公告)日：2024-04-09

    申请号：US18539771

    申请日：2023-12-14

    Applicant: KING FAISAL UNIVERSITY

    Inventor： Christophe Tratrat ,  Michelyne Haroun

    IPC: C07D471/04 ,  A61P35/00

    CPC classification number: C07D471/04 ,  A61P35/00

    Abstract: Novel pyrrolo[2,3-c]isoquinoline-1,2-dione, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The pyrrolo[2,3-c]isoquinoline-1,2-dione compounds, identified as CK2 inhibitors, are useful as anticancer and/or antitumor agents, and as agents for treating other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and other types of diseases such as diabetes, viral infection, neurodegenerative diseases.

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