公开(公告)号：US11376266B2

公开(公告)日：2022-07-05

申请号：US16067906

申请日：2017-01-05

申请人： KEIO UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

发明人： Hideyuki Saya ,  Osamu Nagano ,  Kenji Tsuchihashi ,  Kentaro Suina ,  Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Makoto Matsui ,  Keishiro Tomoda ,  Naoki Yamada ,  Tsukasa Nishimori

IPC分类号： A61K31/635 ,  A61K47/60 ,  A61K9/00

摘要： The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.

公开(公告)号：US20220265836A1

公开(公告)日：2022-08-25

申请号：US17613912

申请日：2020-05-29

申请人： TOKYO INSTITUTE OF TECHNOLOGY ,  KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

发明人： Nobuhiro Nishiyama ,  Yuto Honda ,  Takahiro Nomoto ,  Hiroyasu Takemoto ,  Makoto Matsui ,  Hiroaki Kinoh ,  Kazunori Kataoka ,  Xueying Liu ,  Anjaneyulu Dirisala

IPC分类号： A61K47/64 ,  A61K47/69 ,  A61K47/59 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00

摘要： A complex is provided comprising a conjugate in which a polymer having a boronic acid group and a compound having a diol structure are bonded, and a substance that is complexed with the conjugate.

公开(公告)号：US11890347B2

公开(公告)日：2024-02-06

申请号：US16468199

申请日：2017-12-05

申请人： Tokyo Institute of Technology

发明人： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Abdul-Hackam Ranneh ,  Keishiro Tomoda ,  Takahiro Nomoto ,  Makoto Matsui

IPC分类号： A61K47/59 ,  C08G69/48

CPC分类号： A61K47/59 ,  C08G69/48

摘要： A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.

公开(公告)号：US20200069807A1

公开(公告)日：2020-03-05

申请号：US16468199

申请日：2017-12-05

申请人： Tokyo Institute of Technology

发明人： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Abdul-Hackam Ranneh ,  Keishiro Tomoda ,  Takahiro Nomoto ,  Makoto Matsui

IPC分类号： A61K47/59 ,  C08G69/48

摘要： A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.

公开(公告)号：US11707530B2

公开(公告)日：2023-07-25

申请号：US16326657

申请日：2017-08-17

申请人： TOKYO INSTITUTE OF TECHNOLOGY ,  OSAKA UNIVERSITY

发明人： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Keishiro Tomoda ,  Makoto Matsui ,  Naoki Yamada ,  Yuto Honda ,  Hideshi Ishii ,  Masaki Mori ,  Masamitsu Konno

IPC分类号： A61K47/64 ,  A61K49/14

CPC分类号： A61K47/6455 ,  A61K49/146

摘要： The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.

公开(公告)号：US11555082B2

公开(公告)日：2023-01-17

申请号：US16963864

申请日：2019-02-19

申请人： TOKYO INSTITUTE OF TECHNOLOGY ,  STELLA PHARMA CORPORATION

发明人： Nobuhiro Nishiyama ,  Takahiro Nomoto ,  Yukiya Inoue ,  Ying Yao ,  Kaito Kanamori ,  Hiroyasu Takemoto ,  Makoto Matsui ,  Keishiro Tomoda

IPC分类号： C08F8/42 ,  C08F16/06 ,  A61K47/60 ,  A61P35/00 ,  A61K9/00 ,  A61K31/69

摘要： The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.

公开(公告)号：US20210308271A1

公开(公告)日：2021-10-07

申请号：US16326657

申请日：2017-08-17

申请人： TOKYO INSTITUTE OF TECHNOLOGY ,  OSAKA UNIVERSITY

发明人： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Keishiro Tomoda ,  Makoto Matsui ,  Naoki Yamada ,  Yuto Honda ,  Hideshi Ishii ,  Masaki Mori ,  Masamitsu Konno

IPC分类号： A61K47/64 ,  A61K49/14

摘要： The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.