公开(公告)号：US20240325458A1

公开(公告)日：2024-10-03

申请号：US17793280

申请日：2021-01-18

Applicant: KEIO UNIVERSITY ,  JSR CORPORATION

Inventor： Nobuyoshi HIROSE ,  Kenya HONDA ,  Yuko SATO ,  Koji ATARASHI ,  Seiko NARUSHIMA ,  Yasumichi ARAI ,  Kozue TAKESHITA ,  Satoshi SASAJIMA

IPC: A61K35/74 ,  A61P31/04 ,  C12N1/20 ,  C12N9/04 ,  C12P33/06 ,  G01N33/569

CPC classification number: A61K35/74 ,  A61P31/04 ,  C12N1/20 ,  C12N9/0006 ,  C12P33/06 ,  G01N33/56911 ,  C12Y101/01145 ,  C12Y103/99005 ,  C12Y103/99006

Abstract: The present inventors have found that the content ratios of isoalloLCA, 3-oxoLCA, alloLCA, and 3-oxoalloLCA in the feces of centenarians are higher than those of younger ones, and have also identified gut microbiomes peculiar to centenarians involved in the production of these bile acids. Furthermore, it has been found that these bile acids, enzymes involved in the production thereof, and bacteria producing the enzymes reduce the risk of infection with pathogens, prostate cancer, and the like, and are involved in longevity.

公开(公告)号：US20230024068A1

公开(公告)日：2023-01-26

申请号：US17779286

申请日：2020-11-25

Applicant: JSR CORPORATION ,  TOKYO METROPOLITAN GOVERNMENT ,  KEIO UNIVERSITY

Inventor： Kazuhiko KAKIHANA ,  Kyoko INAMOTO ,  Kenya HONDA ,  Kozue TAKESHITA ,  Yuuko KIRIDOOSHI

IPC: A61K35/74 ,  A61K9/48 ,  A61P37/06

Abstract: The present invention provides a prophylactic or therapeutic composition for graft-versus-host disease (GVHD).
There is provided a prophylactic or therapeutic composition for GVHD, which comprises bacteria belonging to any genus selected from the group consisting of the following genera: Blautia, Clostridium, unclassified Clostridiales, Actinomyces, Parabacteroides, Lachnoclostridium, Bacteroides, Faecalibacterium, unclassified Lachnospiraceae, Roseburia, Ruminococcus, unclassified Firmicutes, Dorea, Phascolarctobacterium, Sutterella, Megamonas, Collinsella, Eubacterium, and Coprococcus, etc., or any combination of bacteria belonging to these genera.

公开(公告)号：US20200038459A1

公开(公告)日：2020-02-06

申请号：US16601192

申请日：2019-10-14

Applicant: TOKYO METROPOLITAN GOVERNMENT ,  The University of Tokyo ,  KEIO UNIVERSITY

Inventor： Kazuhiko Kakihana ,  Masahira HATTORI ,  Kenya HONDA ,  Hiroyoshi NISHIKAWA ,  Hidetoshi MORITA ,  Kozue TAKESHITA

IPC: A61K35/742 ,  A61P37/00 ,  A61K9/48 ,  A61K35/38

Abstract: The present invention provides a composition for preventing or treating a graft-versus-host disease, the composition comprising a fecal microbiota.