公开(公告)号：US20250066343A1

公开(公告)日：2025-02-27

申请号：US18710092

申请日：2022-11-15

Applicant: K-MEDICHEM CO., LTD.

Inventor： Koo Yeon LEE ,  Se-Hui JUNG ,  Hee-Young HEO ,  Ju Eun KIM ,  Chan Bin LEE

IPC: C07D417/06 ,  A61K31/352 ,  A61K31/427 ,  A61K31/453 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/541 ,  C07D311/36 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

Abstract: Provided are a cannabichromenic acid derivative, a method for preparing same, and a composition for cognitive function improvement comprising same, in which the cannabichromenic acid derivative exhibits acetylcholinesterase inhibitory activity and butyrylcholinesterase inhibitory activity, as well as inhibitory activity against monoamine oxidase B, therefore simultaneously treating a decrease in acetylcholine levels in brain tissue and a decrease in blood butyrylcholine levels, shown in patients with dementia, and providing a more effective cognitive function improvement treatment by preventing brain cell damage.