公开(公告)号：US4233215A

公开(公告)日：1980-11-11

申请号：US954218

申请日：1978-10-24

申请人： John S. Driscoll ,  A. Hameed Khan ,  Feng-Te Chou

发明人： John S. Driscoll ,  A. Hameed Khan ,  Feng-Te Chou

IPC分类号： C07D203/14 ,  C07D295/12

CPC分类号： C07D203/14

摘要： The use of aziridinyl quinones as antitumor agents against transplanted tumors in mice is disclosed. A compound which has been found to be particularly effective is the compound 2,5-diaziridinyl-3,6-bis (carboethoxyamino)-1,4-benzoquinone. Treatment is described in connection with several transplanted mouse tumor test systems including various forms of leukemia, for example, as well as B16 melanoma, Lewis lung carcinoma, and the ependymoblastoma brain tumor system.

摘要翻译： 公开了使用氮丙啶醌作为抗小鼠移植肿瘤的抗肿瘤剂。 已经发现特别有效的化合物是化合物2,5-二氮丙啶基-3,6-双（乙氧羰氨基）-1,4-苯醌。 关于包括各种形式的白血病的几种移植的小鼠肿瘤测试系统，例如以及B16黑素瘤，Lewis肺癌和室管膜母细胞瘤脑肿瘤系统描述了治疗。

公开(公告)号：US4704384A

公开(公告)日：1987-11-03

申请号：US332341

申请日：1981-12-18

申请人： John S. Driscoll ,  A. Hameed Khan ,  Feng-Te Chou

发明人： John S. Driscoll ,  A. Hameed Khan ,  Feng-Te Chou

IPC分类号： C07D203/14 ,  A61K31/33

CPC分类号： C07D203/14

摘要： The use of aziridinyl quinones as antitumor agents is disclosed. A compound which has been found to be particularly effective is the compound 2,5-diaziridinyl-3,6-bis (carboethoxyamino)-1,4-benzoquinone. Treatment is described in connection with various forms of leukemia, for example, as well as B16 melanoma, Lewis lung carcinoma, and the ependymoblastoma brain tumor system.

摘要翻译： 公开了使用氮丙啶醌作为抗肿瘤剂。 已经发现特别有效的化合物是化合物2,5-二氮丙啶基-3,6-双（乙氧羰氨基）-1,4-苯醌。 治疗涉及各种形式的白血病，例如，以及B16黑素瘤，Lewis肺癌和室管母细胞瘤脑肿瘤系统。