公开(公告)号：US20240299360A1

公开(公告)日：2024-09-12

申请号：US17760169

申请日：2021-02-03

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd.

发明人： Dong Liu ,  Peng Zhao ,  Jian Liu ,  Linghang Zhuang ,  Fengqi Zhang ,  Xinzhu Zhang ,  Chunying Song ,  Suxing Liu ,  Jing Li

IPC分类号： A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/506 ,  A61K31/55 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

CPC分类号： A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/506 ,  A61K31/55 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Compounds of formula (I) useful as inhibitors of ADAMTS-5 and/or ADAMTS-4, pharmaceutical compositions thereof, and use of them as therapeutic agents for the treatment of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis, are disclosed.