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公开(公告)号：US08173666B2
公开(公告)日：2012-05-08
申请号：US12558395
申请日：2009-09-11
IPC分类号： A61K31/485 , C07D489/02
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学改性的化合物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的化合物的特征不同的特征。
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公开(公告)号：US08440687B2
公开(公告)日：2013-05-14
申请号：US13426521
申请日：2012-03-21
IPC分类号： A61K31/485 , C07D489/08
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US08466276B2
公开(公告)日：2013-06-18
申请号：US12918780
申请日：2009-02-20
IPC分类号： C07H19/056 , A01N43/04 , A61K31/70
CPC分类号： A61K47/48215 , A61K31/7056 , A61K47/60 , C07H19/056
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
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公开(公告)号：US08575196B2
公开(公告)日：2013-11-05
申请号：US13386327
申请日：2010-07-21
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US20120184581A1
公开(公告)日：2012-07-19
申请号：US13386327
申请日：2010-07-21
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学改性的化合物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的化合物的特征不同的特征。
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公开(公告)号：US20110039797A1
公开(公告)日：2011-02-17
申请号：US12918780
申请日：2009-02-20
IPC分类号： A61K31/7056 , C07H19/056 , C07H19/044 , A61P31/12
CPC分类号： A61K47/48215 , A61K31/7056 , A61K47/60 , C07H19/056
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。
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公开(公告)号：US08569343B2
公开(公告)日：2013-10-29
申请号：US13538540
申请日：2012-06-29
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US20120289548A1
公开(公告)日：2012-11-15
申请号：US13538540
申请日：2012-06-29
IPC分类号： A61K31/4468 , A61P25/00 , C07D211/58
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学改性的化合物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的化合物的特征不同的特征。
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公开(公告)号：US20100048602A1
公开(公告)日：2010-02-25
申请号：US12558395
申请日：2009-09-11
IPC分类号： A61K31/439 , C07D489/00 , A61P25/00
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学改性的化合物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的化合物的特征不同的特征。
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公开(公告)号：US20100286084A1
公开(公告)日：2010-11-11
申请号：US12676128
申请日：2008-09-18
申请人： Zhongxu Ren , Jennifer Riggs-Sauthier , Timothy A. Riley , Laurie A. Vander Veen , Aaron S. Hammons
发明人： Zhongxu Ren , Jennifer Riggs-Sauthier , Timothy A. Riley , Laurie A. Vander Veen , Aaron S. Hammons
IPC分类号： A61K31/7052 , C07H19/04 , C07H19/10 , C07H19/20 , C07H19/052 , A61P35/00
CPC分类号： C07H17/02 , A61K47/48215 , A61K47/60
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble, non-peptidic oligomer. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
摘要翻译： 本发明提供了通过共价连接水溶性非肽寡聚物进行化学修饰的小分子药物。 当通过任何多种施用途径施用时，本发明的缀合物显示出优于先前给予的化合物的优点。
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