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1.发明授权Enhanced efficacy basic aluminum halides, antiperspirant active compositions and methods for making 失效增强功效碱性卤化铝，止汗活性组合物和制备方法公开(公告)号：US06902724B1
公开(公告)日：2005-06-07
申请号：US10807996
申请日：2004-03-24
申请人： Jawahar C. Parekh , Pradip Amin
发明人： Jawahar C. Parekh , Pradip Amin
摘要： Disclosed are basic aluminum halides having enhanced antiperspirant efficacy; methods of making such materials and antiperspirant compositions containing such basic aluminum halides, and optionally an amino acid, salts of amino acids, antimicrobial agents, or an organic solvent having at least two carbon atoms and at least one hydroxy group and mixture thereof and methods of making such mixtures. Basic aluminum halides having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder; (b) an aluminum halide; and (c) water at a temperature greater than about 85° C. This reaction is maintained until reaction products having an Al:halide ratio of about 1.2:1 to 1.5:1 and preferably 1.3 to 1.4:1; and a solution solids concentration of about 30-40 weight percent on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography (HPLC) Test Band I of less than 5%, preferably less than 1%, Band II percent aluminum value of 20-60% preferably about 35 to 55%, Band III percent aluminum value of 10 to 35% preferably 15-30% and Band IV value of 15 to 50% and preferably 25 to 35% and sum of peak 3 and 4 areas of at least 45% and no more than 70% and preferably 65%. The enhanced efficacy basic aluminum chloride salts of this invention are more economical to produce, show enhanced efficacy and are more stable compared to the conventional enhanced efficacy aluminum salts which show rapid degradation of Band III to Band II peak areas ratio are less irritant and more skin friendly.
摘要翻译： 公开了具有增强的止汗功效的碱性卤化铝; 制备这种材料的方法和含有这种碱性卤化铝的任选的止汗组合物，和任选的氨基酸，氨基酸，抗微生物剂或具有至少两个碳原子和至少一个羟基的有机溶剂的盐，以及它们的混合物 制造这样的混合物。 具有增强止汗功效的碱性卤化铝通过（a）铝粉与 （b）卤化铝; 在大于约85℃的温度下加入水。该反应保持至Al:卤化物比为约1.2:1至1.5:1，优选1.3至1.4:1的反应产物; 并且获得以无水为基准的约30-40重量％的溶液固体浓度。 该产品的特征在于尺寸排阻色谱（HPLC）测试条带I小于5％，优选小于1％，带II％铝值为20-60％，优选约35至55％，带III％铝值 10至35％，优选15-30％，并且带IV值为15至50％，优选25至35％，峰3和4面积之和为至少45％且不超过70％，优选为65％。 本发明的增强的功效碱性氯化铝盐与常规增强的功效性铝盐相比，更有效地生产，显示出增强的功效并且更稳定，显示出带III快速降解至Band II峰面积比较少刺激性和更多皮肤 友善。
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2.发明授权Enhanced efficacy basic aluminum halides/metal cation salt, antiperspirants actives and compositions containing such materials and methods for making 失效增强功效碱性卤化铝/金属阳离子盐，止汗剂活性剂和含有这些材料的组合物和制备方法公开(公告)号：US07014843B2
公开(公告)日：2006-03-21
申请号：US10807872
申请日：2004-03-24
申请人： Jawahar C. Parekh , Pradip Amin
发明人： Jawahar C. Parekh , Pradip Amin
摘要： Disclosed are aqueous antiperspirant active compositions comprising an admixtures of basic aluminum halides and a metal cation salts which yield enhanced antiperspirant efficacy; and methods of making such antiperspirant compositions. The basic aluminum halides, optionally contain an amino acid or salts of amino acids, and/or antimicrobial agent and are combined with a metal cation antiperspirant (e.g., Ti salt or Hf salt or Sn salt or Zr salt) and optionally with a organic solvent having at least two carbon atoms and at least one hydroxy group and mixtures thereof and methods of making such mixtures. Basic aluminum halides having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder; (b) an aluminum halide; and (c) water at a temperature greater than about 85° C. This reaction is maintained until reaction products having an Al:halide ratio of about 1.2 to 1.5 and preferably 1.3 to 1.4:1; and a solution solids concentration of about 30-40 weight percent on an anhydrous basis are obtained. The basic aluminum halide of this invention are characterized as having a Size Exclusion Chromatography (HPLC) Test Band I of less than 5%, preferably less than 1%, Band II percent aluminum value of 20%-60% preferably about 35% to 55%, Band III percent aluminum value of 10% to 35% preferably 15%-30% and Band IV value of 15% to 50% preferably 25% to 35% and sum of peak 3 and 4 areas of at least 45% and no more than 70% and preferably 65%.
摘要翻译： 公开了含有止汗剂活性组合物，其包含碱性卤化铝和金属阳离子盐的混合物，其产生增强的止汗效力; 以及制备这种止汗组合物的方法。 碱性卤化铝，任选地含有氨基酸或氨基酸盐和/或抗微生物剂，并与金属阳离子止汗剂（例如Ti盐或Hf盐或Sn盐或Zr盐）和任选地与有机溶剂 具有至少两个碳原子和至少一个羟基及其混合物，以及制备此类混合物的方法。 具有增强止汗功效的碱性卤化铝通过（a）铝粉与 （b）卤化铝; 并且（c）在大于约85℃的温度下的水。保持该反应直到Al:卤化物比为约1.2至1.5，优选1.3至1.4:1的反应产物; 并且获得以无水为基准的约30-40重量％的溶液固体浓度。 本发明的碱性卤化铝的特征在于尺寸排阻色谱（HPLC）测试条带I小于5％，优选小于1％，带II％铝值为20％-60％，优选约35％至55 ％，III组铝值为10％至35％，优选为15％-30％，Band IV值为15％至50％，优选25％至35％，峰3和4面积之和为至少45％，无 大于70％，优选65％。
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3.发明申请ENHANCED EFFICACY BASIC ALUMINUM HALIDES/METAL CATION SALT, ANTIPERSPIRANTS ACTIVES AND COMPOSITIONS CONTAINING SUCH MATERIALS AND METHODS FOR MAKING 失效增强效能基本铝盐/金属盐，抗菌活性剂和含有这些材料的组合物和制备方法公开(公告)号：US20050214234A1
公开(公告)日：2005-09-29
申请号：US10807872
申请日：2004-03-24
申请人： Jawahar Parekh , Pradip Amin
发明人： Jawahar Parekh , Pradip Amin
摘要： Disclosed are aqueous antiperspirant active compositions comprising an admixtures of basic aluminum halides and a metal cation salts which yield enhanced antiperspirant efficacy; and methods of making such antiperspirant compositions. The basic aluminum halides, optionally contain an amino acid or salts of amino acids, and/or antimicrobial agent and are combined with a metal cation antiperspirant (e.g., Ti salt or Hf salt or Sn salt or Zr salt) and optionally with a organic solvent having at least two carbon atoms and at least one hydroxy group and mixtures thereof and methods of making such mixtures. Basic aluminum halides having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder; (b) an aluminum halide; and (c) water at a temperature greater than about 85° C. This reaction is maintained until reaction products having an Al:halide ratio of about 1.2 to 1.5 and preferably 1.3 to 1.4:1; and a solution solids concentration of about 30-40 weight percent on an anhydrous basis are obtained. The basic aluminum halide of this invention are characterized as having a Size Exclusion Chromatography (HPLC) Test Band I of less than 5%, preferably less than 1%, Band II percent aluminum value of 20%-60% preferably about 35% to 55%, Band III percent aluminum value of 10% to 35% preferably 15%-30% and Band IV value of 15% to 50% preferably 25% to 35% and sum of peak 3 and 4 areas of at least 45% and no more than 70% and preferably 65%.
摘要翻译： 公开了含有止汗剂活性组合物，其包含碱性卤化铝和金属阳离子盐的混合物，其产生增强的止汗效力; 以及制备这种止汗组合物的方法。 碱性卤化铝，任选地含有氨基酸或氨基酸盐和/或抗微生物剂，并与金属阳离子止汗剂（例如Ti盐或Hf盐或Sn盐或Zr盐）和任选地与有机溶剂 具有至少两个碳原子和至少一个羟基及其混合物，以及制备此类混合物的方法。 具有增强止汗功效的碱性卤化铝通过（a）铝粉与 （b）卤化铝; 并且（c）在大于约85℃的温度下的水。保持该反应直到Al:卤化物比为约1.2至1.5，优选1.3至1.4:1的反应产物; 并且获得以无水为基准的约30-40重量％的溶液固体浓度。 本发明的碱性卤化铝的特征在于尺寸排阻色谱（HPLC）测试条带I小于5％，优选小于1％，带II％铝值为20％-60％，优选约35％至55 ％，III组铝值为10％至35％，优选为15％-30％，Band IV值为15％至50％，优选25％至35％，峰3和4面积之和为至少45％，无 大于70％，优选65％。
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4.发明申请Fragrance friendly and cost effective antiperspirant actives and method of making the same 失效香味友好和具有成本效益的止汗活性物质及其制备方法公开(公告)号：US20050276773A1
公开(公告)日：2005-12-15
申请号：US10865397
申请日：2004-06-10
申请人： Jawahar Parekh , Pradip Amin , Chung Shin
发明人： Jawahar Parekh , Pradip Amin , Chung Shin
摘要： A cost effective process is provided for making stable, efficacious, amino acid and polyhydric alcohol free concentrated aqueous aluminum zirconium salt solutions. Absence of amino acid, low iron content and low trace metal impurity levels improve compatibility with fragrances and minimizes the probability of the product color change and possibly fabric staining significantly. The novel aluminum zirconium actives also minimize iron contribution to underarm area that supports growth of microflora which is responsible for axillary malodour by the biotransformation of nonodorous precursors present in perspiration. The astringent complexes of the present invention may be obtained in solution or dry powder form. As a result, the complexes are satisfactory for use in any of wide variety of conventional antiperspirant forms.
摘要翻译： 提供了一种成本有效的方法，用于制备稳定，有效的氨基酸和多元醇的浓盐酸铝水溶液。 缺乏氨基酸，低铁含量和低痕量金属杂质水平提高了与香料的相容性，并最大限度地降低了产品颜色变化和织物染色显着的可能性。 新型铝锆活性物质也使铁对腋下区域的贡献最小化，其支持微生物群落的生长，微生物群落通过出汗中存在的无臭前体的生物转化而引起腋窝恶臭。 本发明的收敛剂可以以溶液或干粉形式获得。 结果，复合物可以用于各种常规止汗剂形式中的任何一种。
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