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公开(公告)号：US11505546B2
公开(公告)日：2022-11-22
申请号：US17212338
申请日：2021-03-25
发明人： Jesus Alcazar , Michael K. Ameriks , Cynthia B. Berry , Pablo Garcia-Reynaga , Andrew V. Samant , J. A. Vega-Ramiro
IPC分类号： C07D413/06 , C07D413/14 , C07D401/06 , C07D401/14 , C07D403/06
摘要： Azaspirocycle compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein X, R1, R2a, R2b, R3, m, n, o, and p are defined herein.
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公开(公告)号：US20230227438A1
公开(公告)日：2023-07-20
申请号：US18051130
申请日：2022-10-31
发明人： Jesus Alcazar , Michael K. Ameriks , Cynthia B. Berry , Pablo Garcia-Reynaga , Andrew V. Samant , J. A. Vega-Ramiro
IPC分类号： C07D413/06 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14
CPC分类号： C07D413/06 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14
摘要： Azaspirocycle compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions:
wherein X, R1, R2a, R2b, R3, m, n, o, and p are defined herein.-
公开(公告)号：US20220081428A1
公开(公告)日：2022-03-17
申请号：US17212338
申请日：2021-03-25
发明人： Jesus Alcazar , Michael K. Ameriks , Cynthia B. Berry , Pablo Garcia-Reynaga , Andrew V. Samant , J. A. Vega-Ramiro
IPC分类号： C07D413/06 , C07D413/14 , C07D401/06 , C07D401/14 , C07D403/06
摘要： Azaspirocycle compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein X, R1, R2a, R2b, R3, m, n, o, and p are defined herein.
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公开(公告)号：US20240239776A1
公开(公告)日：2024-07-18
申请号：US18530758
申请日：2023-12-06
发明人： Jesus Alcazar , Michael K. Ameriks , Cynthia B. Berry , Pablo Garcia-Reynaga , Andrew V. Samant , J. A. Vega-Ramiro
IPC分类号： C07D413/06 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14
CPC分类号： C07D413/06 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14
摘要： Azaspirocycle compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions:
wherein X, R1, R2, R2b, R3, m, n, o, and p are defined herein.-
公开(公告)号：US11897872B2
公开(公告)日：2024-02-13
申请号：US18051130
申请日：2022-10-31
发明人： Jesus Alcazar , Michael K. Ameriks , Cynthia B. Berry , Pablo Garcia-Reynaga , Andrew V. Samant , J. A. Vega-Ramiro
IPC分类号： C07D413/06 , C07D413/14 , C07D401/06 , C07D401/14 , C07D403/06
CPC分类号： C07D413/06 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14
摘要： Azaspirocycle compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions:
wherein X, R1, R2a, R2b, R3, m, n, o, and p are defined herein.
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