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公开(公告)号：US20180015129A1
公开(公告)日：2018-01-18
申请号：US15636140
申请日：2017-06-28
Applicant: Janssen Biotech, Inc.
Inventor： Ian R. Harris , Nadine Dejneka
IPC: A61K9/00
Abstract: Methods and compositions for treating ophthalmic disease, reducing retinal neovascularization and retinal vascular leakage using progenitor cells, such as postpartum-derived cells, and conditioned media from the cells, are disclosed.
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公开(公告)号：US20190134100A1
公开(公告)日：2019-05-09
申请号：US16178083
申请日：2018-11-01
Applicant: Janssen Biotech, Inc.
Inventor： Jing Cao , Ian R. Harris
IPC: A61K35/51 , A61P27/02 , C12N5/0775
Abstract: Methods and compositions for treating ophthalmic disease and reducing retinal neovascularization using progenitor cells, such as postpartum-derived cells, and conditioned media produced from the cells, are disclosed.
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公开(公告)号：US20180344777A1
公开(公告)日：2018-12-06
申请号：US15988821
申请日：2018-05-24
Applicant: Janssen Biotech, Inc.
Inventor： Ian R. Harris , Nadine S. Dejneka
Abstract: Methods and compositions for treating ophthalmic disease, in particular retinal degeneration, including modulating Müller glia, restoring retinal synaptic connectivity and forming α2δ1-containing synapses, using postpartum-derived cells are disclosed.
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Patent Agency Ranking
公开(公告)号：US20170080033A1
公开(公告)日：2017-03-23
申请号：US15366947
申请日：2016-12-01
Applicant: Janssen Biotech, Inc.
Inventor： Ian R. Harris , Jing Cao , Nadine Dejneka
CPC classification number: A61K35/51 , A61K9/0048 , A61K45/06
Abstract: Methods and compositions for treating and reducing retinal degeneration using progenitor cells and conditioned media from progenitor cells, such as postpartum-derived cells are disclosed. Trophic factors and other agents secreted by the progenitor cells that protect retinal cells and inhibit apoptosis of retinal cells such as photoreceptor cells are also disclosed.
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公开(公告)号：US20160166619A1
公开(公告)日：2016-06-16
申请号：US14960006
申请日：2015-12-04
Applicant: Janssen Biotech, Inc.
Inventor： Ian R. Harris , Jing Cao , Nadine Dejneka
CPC classification number: A61K35/51 , A61K9/0048
Abstract: Methods and compositions for treating and reducing retinal degeneration using progenitor cells and conditioned media from progenitor cells, such as postpartum-derived cells are disclosed. Trophic factors and other agents secreted by the progenitor cells that protect retinal cells and inhibit apoptosis of retinal cells such as photoreceptor cells are also disclosed.
Abstract translation: 公开了使用祖细胞治疗和减少视网膜变性的方法和组合物，以及来自祖细胞例如产后衍生细胞的条件培养基。 还公开了由保护视网膜细胞并抑制视网膜细胞如感光细胞凋亡的祖细胞分泌的营养因子和其它药剂。
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公开(公告)号：US20180346874A1
公开(公告)日：2018-12-06
申请号：US15988782
申请日：2018-05-24
Applicant: Janssen Biotech, Inc.
Inventor： Ian R. Harris , Nadine S. Dejneka
Abstract: The invention provides for methods of obtaining cells from mammalian, preferably human, postpartum umbilical cord arterial tissue and use of these cells to treat ocular degenerative conditions. In particular, methods of the invention result in the isolation of a homogenous population of human postpartum umbilical cord arterial tissue-derived cells. In certain embodiments, the cells: express CD13, CD90, NG2, and HLA-ABC; do not express one or more of CD31, CD34, CD45, CD117, FSP1, and E-cadherin. In other embodiments, the cells secrete one or more of thrombospondin-1, BDNF and sVEGFR1.
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公开(公告)号：US20170157179A1
公开(公告)日：2017-06-08
申请号：US15366599
申请日：2016-12-01
Applicant: Janssen Biotech, Inc.
Inventor： Ian R. Harris , Jing Cao , Nadine Dejneka
CPC classification number: A61K35/51 , A61K9/0048 , A61K35/50 , A61P27/02
Abstract: Methods and compositions for treating and reducing retinal degeneration using progenitor cells and conditioned media from progenitor cells, such as postpartum-derived cells are disclosed. Genetic factors and receptors expressed by the progenitor cells that aid in protection of retinal cells and inhibition of apoptosis of retinal cells such as photoreceptor cells are also disclosed.
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公开(公告)号：US20160346331A1
公开(公告)日：2016-12-01
申请号：US15238976
申请日：2016-08-17
Applicant: Janssen Biotech, Inc.
Inventor： Xiaozhen Wang , Ian R. Harris , Jeffrey S. Kennedy , Jing Yang , Susan Munga
CPC classification number: A61K35/34 , A61K9/0019 , A61K35/12 , A61K45/06 , C12N5/0657 , C12N5/0662 , C12N2509/00
Abstract: The present invention is directed to methods and compositions for repairing damaged myocardium using human cardiac tissue-derived cells. In particular, the present invention provides methods and compositions for repairing damaged myocardium using expanded human cardiac tissue-derived cells that do not express telomerase.
Abstract translation: 本发明涉及使用人心脏组织衍生的细胞修复受损心肌的方法和组合物。 特别地，本发明提供使用不表达端粒酶的扩增的人心脏组织来源的细胞修复受损心肌的方法和组合物。
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