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Patent Agency Ranking
1.发明授权Sensitization of cancer cells to DNA damage by inhibiting kinases essential for DNA damage checkpoint control 有权通过抑制DNA损伤检查点控制所必需的激酶，使癌细胞对DNA损伤的敏感公开(公告)号：US09421203B2
公开(公告)日：2016-08-23
申请号：US14564186
申请日：2014-12-09
Applicant: Institute for Cancer Research
Inventor： Timothy Yen , Neil Beeharry
IPC: A61K31/496 , A61K31/7068
CPC classification number: A61K31/496 , A61K31/7068 , A61K2300/00
Abstract: The invention provides methods for overriding cell cycle arrest in a tumor cell, which comprise inducing DNA damage in the cell, and contacting the cell with an amount of bosutinib or a bosutinib isomer effective to inhibit one or more kinase constituents of a DNA damage checkpoint pathway. The invention also provides novel bosutinib isomers, as well as compositions of the novel isomers and the bosutinib isomer 3,5-dichloro-4-methoxyaniline.
Abstract translation: 本发明提供了覆盖肿瘤细胞中的细胞周期阻滞的方法，其包括诱导细胞中的DNA损伤，并使细胞与一定量的有效抑制DNA损伤检查点通路的一个或多个激酶成分的波苏替尼或波苏替尼异构体接触 。 本发明还提供新颖的波生坦异构体，以及新异构体的组合物和bosutinib异构体3,5-二氯-4-甲氧基苯胺。
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2.发明申请SENSITIZATION OF CANCER CELLS TO DNA DAMAGE BY INHIBITING KINASES ESSENTIAL FOR DNA DAMAGE CHECKPOINT CONTROL 有权通过抑制动物DNA损伤检测点控制的基础，癌细胞对DNA损伤的敏感性公开(公告)号：US20150133466A1
公开(公告)日：2015-05-14
申请号：US14564186
申请日：2014-12-09
Inventor： Timothy Yen , Neil Beeharry
IPC: A61K31/496
CPC classification number: A61K31/496 , A61K31/7068 , A61K2300/00
Abstract: The invention provides methods for overriding cell cycle arrest in a tumor cell, which comprise inducing DNA damage in the cell, and contacting the cell with an amount of bosutinib or a bosutinib isomer effective to inhibit one or more kinase constituents of a DNA damage checkpoint pathway. The invention also provides novel bosutinib isomers, as well as compositions of the novel isomers and the bosutinib isomer 3,5-dichloro-4-methoxyaniline.
Abstract translation: 本发明提供了覆盖肿瘤细胞中的细胞周期阻滞的方法，其包括诱导细胞中的DNA损伤，并使细胞与一定量的有效抑制DNA损伤检查点通路的一个或多个激酶成分的波苏替尼或波苏替尼异构体接触 。 本发明还提供新颖的波生坦异构体，以及新异构体的组合物和bosutinib异构体3,5-二氯-4-甲氧基苯胺。
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3.发明授权公开(公告)号：US10220051B2
公开(公告)日：2019-03-05
申请号：US14540428
申请日：2014-11-13
Applicant: Institute for Cancer Research
Inventor： Alfonso Bellacosa , Timothy Yen , Neil Beeharry , Mitchell Smith , Rossella Tricarico , Vikram Bhattacharjee , Pietro Mancuso
IPC: A61K31/7068 , A61K31/4184 , A61K31/122 , A61K31/546 , A61K31/277 , A61K31/7088 , C12N15/113
Abstract: The invention provides methods for enhancing the cytotoxicity of DNA damage in cancer cells that express thymine DNA glycosylase, and treating tumors accordingly. The methods comprise inhibiting the expression or biologic activity of thymine DNA glycosylase, and inducing DNA damage in the cancer cells. DNA damage may be induced by administration of bendamustine or gemcitabine to the cancer cells.
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4.发明授权Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer 有权组合DNA修复抑制与苯达莫司汀或吉西他滨治疗癌症公开(公告)号：US08927516B2
公开(公告)日：2015-01-06
申请号：US13836414
申请日：2013-03-15
Applicant: Institute for Cancer Research
Inventor： Alfonso Bellacosa , Timothy Yen , Neil Beeharry , Mitchell Smith
IPC: C12N15/113 , A61K31/4184 , A61K31/7068 , A61K31/7088
CPC classification number: C12N15/1137 , A61K31/4184 , A61K31/7068 , A61K31/7088 , C12N2310/14 , C12N2320/31 , C12Y302/02029 , A61K2300/00
Abstract: The invention provides methods for enhancing the cytotoxicity of DNA damage in cancer cells that express thymine DNA glycosylase, and treating tumors accordingly. The methods comprise inhibiting the expression or biologic activity of thymine DNA glycosylase, and inducing DNA damage in the cancer cells. DNA damage may be induced by administration of bendamustine or gemcitabine to the cancer cells.
Abstract translation: 本发明提供了增强表达胸腺嘧啶DNA糖基化酶的癌细胞中DNA损伤的细胞毒性的方法，并相应地治疗肿瘤。 所述方法包括抑制胸腺嘧啶DNA糖基化酶的表达或生物活性，并诱导癌细胞中的DNA损伤。 DNA损伤可以通过给予癌细胞给予苯达莫司汀或吉西他滨诱导。
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5.发明申请公开(公告)号：US20130303588A1
公开(公告)日：2013-11-14
申请号：US13836414
申请日：2013-03-15
Inventor： Alfonso Bellacosa , Timothy Yen , Neil Beeharry , Mitchell Smith
IPC: C12N15/113
CPC classification number: C12N15/1137 , A61K31/4184 , A61K31/7068 , A61K31/7088 , C12N2310/14 , C12N2320/31 , C12Y302/02029 , A61K2300/00
Abstract: The invention provides methods for enhancing the cytotoxicity of DNA damage in cancer cells that express thymine DNA glycosylase, and treating tumors accordingly. The methods comprise inhibiting the expression or biologic activity of thymine DNA glycosylase, and inducing DNA damage in the cancer cells. DNA damage may be induced by administration of bendamustine or gemcitabine to the cancer cells.
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