公开(公告)号：US10398647B2

公开(公告)日：2019-09-03

申请号：US15788920

申请日：2017-10-20

Applicant: Industrial Technology Research Institute

Inventor： Wen-Hsuan Chiang ,  Yu-Wen Lo ,  Felice Cheng ,  Maggie Lu ,  Ya-Ling Chiu

IPC: A61K9/06 ,  A61K47/10 ,  A61K47/34 ,  A61K31/704 ,  A61K38/38 ,  A61K38/17 ,  C07K16/32 ,  A61K39/395 ,  A61K38/26 ,  A61K33/30 ,  A61K47/42 ,  A61K39/00 ,  A61K9/00

Abstract: A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG) containing terminal thiol groups, wherein the hydrogel composition has a pH value ranging from 4.0 to 6.5. A drug delivery system is also provided. The drug delivery system includes the above-mentioned hydrogel composition, and a pharmaceutically active ingredient encapsulated in the hydrogel composition.

公开(公告)号：US11801310B2

公开(公告)日：2023-10-31

申请号：US16232601

申请日：2018-12-26

Applicant: Industrial Technology Research Institute

Inventor： Wen-Chia Huang ,  Yen-Jen Wang ,  Felice Cheng ,  Chia-Ching Chen ,  Shao-Chan Yin ,  Chien-Lin Pan ,  Tsan-Lin Hu ,  Meng-Nan Lin ,  Kuo-Kuei Huang ,  Maggie Lu ,  Chih-Peng Liu

IPC: A61K47/69 ,  A61K47/38 ,  A61K47/40 ,  A61K31/4439 ,  A61K31/569 ,  A61K9/00 ,  A61K47/65 ,  A61K9/08

CPC classification number: A61K47/6951 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/4439 ,  A61K31/569 ,  A61K47/38 ,  A61K47/40 ,  A61K47/65

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition includes about 40-99.5% by weight of cyclodextrin and/or derivatives thereof; about 0.05-10% by weight of at least one water-soluble polymer; and about 0.05-60% by weight of at least one water-soluble stabilizer.

公开(公告)号：US20180169262A1

公开(公告)日：2018-06-21

申请号：US15830272

申请日：2017-12-04

Applicant: Industrial Technology Research Institute

Inventor： Maggie Lu ,  May-Hua Chang ,  Jenn-Tsang Hwang ,  Ping-Fu Cheng ,  Li-Wen Chang ,  Yi-Ju Ko ,  Chi-Y Hung ,  Chun-Min Liu ,  Chia-Yu Fan

IPC: A61K47/68 ,  A61K31/4745 ,  A61K47/64 ,  C07K16/30

CPC classification number: A61K47/6889 ,  A61K31/4745 ,  A61K47/64 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6855 ,  A61P35/00 ,  C07K16/30

Abstract: A linker-drug represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), C is a conjugator, L is a linker unit, D is a toxin unit, and n is an integer ranging from 1 to 4. The structure of the conjugator is represented by formula (II). In formula (II), X is a leaving group, each of R1 and R2 is independently a single bond or —NH—, and Z is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) employing the above linker-drug is also provided.