公开(公告)号：US20230144051A1

公开(公告)日：2023-05-11

申请号：US18046303

申请日：2022-10-13

申请人： Incyte Corporation

发明人： Qinda YE ,  Matthew MCCAMMANT ,  Rocco POLICARPO ,  Artem SHVARTSBART ,  Wenyu ZHU ,  Jeremy ROACH ,  Gia HOANG ,  Bin HU ,  Gencheng LI ,  Robert SUSICK ,  Padmaja POLAM ,  Fenglei ZHANG ,  Chao QI ,  Xiaozhao WANG ,  Wenqing YAO ,  Alexander Sokolsky ,  Haolin YIN ,  Le ZHAO ,  Peter Carlsen

IPC分类号： C07D471/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61P35/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.