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公开(公告)号：US11369591B2
公开(公告)日：2022-06-28
申请号：US15152739
申请日：2016-05-12
申请人： Incept, LLC
发明人： Peter Jarrett , Rami El-Hayek , Timothy S. Jarrett , Charles D. Blizzard , Amarpreet S. Sawhney
IPC分类号： A01N43/00 , A01N43/46 , A61K31/55 , A61K31/436 , A61K31/44 , A61K31/404 , A61K31/502 , A61K31/496 , A61K31/56 , A61K31/517 , A61K31/444 , A61K9/00
摘要： Drug delivery involving hydrogels as used for various medical conditions, and includes hydrogels formed in an eye with extended drug release times. An embodiment of the invention is a method of delivering a therapeutic agent to a tissue comprising forming a hydrogel in situ in an eye with a therapeutic agent dispersed in the hydrogel, the agent having a low solubility in water. The agent may be essentially insoluble in water. The hydrogel may be made so that 50% to 100% w/w of the agent is released when the hydrogel is from 100% to 50% persistent, with the persistence being a measure of the dry weight of the hydrogel relative to an initial dry weight of the hydrogel.
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公开(公告)号：US20160166504A1
公开(公告)日：2016-06-16
申请号：US14965258
申请日：2015-12-10
申请人： Incept, LLC
IPC分类号： A61K9/00 , A61K9/50 , A61K39/395
CPC分类号： A61K9/0051 , A61K9/50 , A61K39/3955 , A61K47/10
摘要： Materials and methods for treating a patient, optionally a patient with an eye disease, comprising providing a collection of particles that comprise a first biodegradable material that is a hydrogel or a xerogel and a therapeutic agent, with the first material, before biodegradation, having a rate of release for the therapeutic agent as measured in physiological solution, and forming a second hydrogel ex vivo or in situ on a tissue of the patient at a site of intended use, optionally at or near an eye, that at least partially coats the collection of particles. The agent is released to treat the patient.
摘要翻译： 用于治疗患者，任选地患有眼睛疾病的患者的材料和方法，包括在生物降解之前提供包含作为第一种材料的水凝胶或干凝胶和治疗剂的第一可生物降解材料的颗粒的集合， 在生理溶液中测量的治疗剂的释放速率，以及在预期用途的部位（任选地在眼睛附近或眼睛附近）离体或原位形成患者组织上的第二水凝胶，其至少部分地涂覆所述收集 的颗粒。 该药物被释放以治疗患者。
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公开(公告)号：US20220370419A1
公开(公告)日：2022-11-24
申请号：US17830968
申请日：2022-06-02
申请人： Incept, LLC
发明人： Peter Jarrett , Rami El-Hayek , Timothy S. Jarrett , Charles D. Blizzard , Amarpreet S. Sawhney
IPC分类号： A61K31/436 , A61K31/44 , A61K31/404 , A61K31/502 , A61K31/496 , A61K31/56 , A61K31/517 , A61K31/444 , A61K9/00
摘要： Drug delivery involving hydrogels as used for various medical conditions, and includes hydrogels formed in an eye with extended drug release times. An embodiment of the invention is a method of delivering a therapeutic agent to a tissue comprising forming a hydrogel in situ in an eye with a therapeutic agent dispersed in the hydrogel, the agent having a low solubility in water. The agent may be essentially insoluble in water. The hydrogel may be made so that 50% to 100% w/w of the agent is released when the hydrogel is from 100% to 50% persistent, with the persistence being a measure of the dry weight of the hydrogel relative to an initial dry weight of the hydrogel.
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公开(公告)号：US20210177975A1
公开(公告)日：2021-06-17
申请号：US17131242
申请日：2020-12-22
申请人： Incept, LLC
摘要： Serial-solvent biomaterials are described. Embodiments include materials made in an organic solvent that are stripped of the solvent and used in a patient, where they imbibe water and form a hydrogel. These materials are useful for, among other things, delivering therapeutic agents, tissue augmentation, and radiological marking.
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公开(公告)号：US20210128478A1
公开(公告)日：2021-05-06
申请号：US16999504
申请日：2020-08-21
申请人： Incept, LLC
发明人： Peter Jarrett , Michael J. McGrath , Timothy S. Jarrett , Rami El-Hayek , Andrew C. Vanslette , Courtney A. Rosales , Charles D. Blizzard , Amarpreet S. Sawhney
IPC分类号： A61K9/20 , A61K47/10 , A61K9/00 , A61K31/4439
摘要： Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.
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公开(公告)号：US20170143636A1
公开(公告)日：2017-05-25
申请号：US15360430
申请日：2016-11-23
申请人： Incept, LLC
发明人： Peter Jarrett , Michael J. McGrath , Timothy S. Jarrett , Rami El-Hayek , Andrew C. Vanslette , Courtney A. Rosales , Charles D. Blizzard , Amarpreet S. Sawhney
IPC分类号： A61K9/20 , A61K31/4439 , A61K9/00
摘要： Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.
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公开(公告)号：US20160045602A1
公开(公告)日：2016-02-18
申请号：US14926707
申请日：2015-10-29
申请人： Incept, LLC
CPC分类号： A61K47/34 , A61K9/0051 , A61K9/06 , A61K38/38 , C07K16/00
摘要： Serial-solvent biomaterials are described. Embodiments include materials made in an organic solvent that are stripped of the solvent and used in a patient, where they imbibe water and form a hydrogel. These materials are useful for, among other things, delivering therapeutic agents, tissue augmentation, and radiological marking.
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公开(公告)号：US11938223B2
公开(公告)日：2024-03-26
申请号：US17859820
申请日：2022-07-07
申请人： Incept, LLC
发明人： Peter Jarrett , Michael J. McGrath , Timothy S. Jarrett , Rami El-Hayek , Andrew C. Vanslette , Courtney A Rosales , Charles D. Blizzard , Amarpreet S. Sawhney
IPC分类号： A61K47/10 , A61K9/00 , A61K9/20 , A61K31/4439 , A61P27/02
CPC分类号： A61K9/2072 , A61K9/0051 , A61K9/2031 , A61K31/4439 , A61K47/10
摘要： Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.
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公开(公告)号：US11890343B2
公开(公告)日：2024-02-06
申请号：US17131242
申请日：2020-12-22
申请人： Incept, LLC
CPC分类号： A61K47/34 , A61K9/06 , A61K38/38 , C07K16/00 , A61K9/0051
摘要： Serial-solvent biomaterials are described. Embodiments include materials made in an organic solvent that are stripped of the solvent and used in a patient, where they imbibe water and form a hydrogel. These materials are useful for, among other things, delivering therapeutic agents, tissue augmentation, and radiological marking.
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公开(公告)号：US10786462B2
公开(公告)日：2020-09-29
申请号：US16533331
申请日：2019-08-06
申请人： Incept, LLC
发明人： Peter Jarrett , Michael J. McGrath , Timothy S. Jarrett , Rami El-Hayek , Andrew C. Vanslette , Courtney A. Rosales , Charles D. Blizzard , Amarpreet S. Sawhney
IPC分类号： A61K47/10 , A61K9/00 , A61K9/20 , A61K31/4439
摘要： Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.
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