公开(公告)号：US20250034227A1

公开(公告)日：2025-01-30

申请号：US18785378

申请日：2024-07-26

Applicant: Immatics Biotechnologies GmbH

Inventor： Felix UNVERDORBEN ,  Sebastian BUNK ,  Martin HOFMANN ,  Meike HUTT ,  Timo MANZ ,  Nadine ASCHMONEIT ,  Maike JAWORSKI ,  Lena SCHMOHL ,  Claudia WAGNER ,  Dominik MAURER ,  Heiko SCHUSTER ,  Nora TREIBER

IPC: C07K14/725 ,  A61K38/00 ,  A61P35/00

Abstract: The present invention relates to antigen binding proteins that specifically bind to a tumor expressed melanoma-associated antigen (MAGE) B2 antigenic peptide in a complex with MHC. The antigen binding proteins are provided for use in the treatment of MAGEB2-expressing cancers. Further provided are nucleic acids encoding the antigen binding proteins, vectors comprising the nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins.