公开(公告)号：US20180071384A1

公开(公告)日：2018-03-15

申请号：US15560462

申请日：2016-03-24

Applicant: IQUR LIMITED

Inventor： Michael Anthony Whelan ,  Robert A. Field ,  David J. Rowlands

IPC: A61K39/29 ,  A61K39/02 ,  A61K39/385 ,  C07K14/02 ,  C12N7/00

CPC classification number: A61K39/292 ,  A61K39/0208 ,  A61K39/385 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/64 ,  A61K2039/70 ,  C07K14/005 ,  C07K14/02 ,  C12N7/00 ,  C12N2730/10122 ,  C12N2730/10123 ,  C12N2730/10134 ,  C12N2730/10151 ,  C12N2730/10171

Abstract: The invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sequence of the formula XpZqXr in an e1 loop, wherein X is a negatively charged amino acid residue, Z is a positively charged amino acid residue, and p, q N and r are each independently an integer from 1 to 12, and wherein a sugar is attached to a Z residue. The protein may comprise a first and a second copy of HBcAg in tandem, wherein one or both copies of HBcAg has a sugar attached to the e1 loop. The first copy may have a sugar attached to the e1 loop and the second copy may comprise a peptide epitope in the e1 loop. The protein may be used to induce an immune response against the sugar and hence act as a vaccine.

公开(公告)号：US09950050B2

公开(公告)日：2018-04-24

申请号：US15119367

申请日：2015-02-18

Applicant: IQUR LIMITED

Inventor： Michael Anthony Whelan ,  Robert A. Field ,  David J. Rowlands

IPC: A61K39/385 ,  A61K39/02 ,  A61K39/12 ,  A61K39/29 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/0208 ,  A61K39/12 ,  A61K39/292 ,  A61K39/385 ,  A61K2039/70 ,  C12N7/00 ,  C12N2730/10134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/412 ,  Y02A50/466 ,  Y02A50/484

Abstract: The invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sugar attached to an e1 loop. The protein may comprise a first and a second copy of HBcAg in tandem, wherein one or both copies of HBcAg has a sugar attached to the e1 loop. The first copy may have a sugar attached to the e1 loop and the second copy may comprise a peptide epitope in the e1 loop. The protein may be used to induce an immune response against the sugar and hence act as a vaccine.

公开(公告)号：US20170049871A1

公开(公告)日：2017-02-23

申请号：US15119367

申请日：2015-02-18

Applicant: IQUR LIMITED

Inventor： Michael Anthony Whelan ,  Robert A. Field ,  David J. Rowlands

IPC: A61K39/02 ,  C12N7/00 ,  A61K39/29

CPC classification number: A61K39/0208 ,  A61K39/12 ,  A61K39/292 ,  A61K39/385 ,  A61K2039/70 ,  C12N7/00 ,  C12N2730/10134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/412 ,  Y02A50/466 ,  Y02A50/484

Abstract: The invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sugar attached to an e1 loop. The protein may comprise a first and a second copy of HBcAg in tandem, wherein one or both copies of HBcAg has a sugar attached to the e1 loop. The first copy may have a sugar attached to the e1 loop and the second copy may comprise a peptide epitope in the e1 loop. The protein may be used to induce an immune response against the sugar and hence act as a vaccine.

Abstract translation: 本发明提供了包含与e1环连接的糖的乙型肝炎核心抗原（HBcAg）的蛋白质。 蛋白质可以包含串联的HBcAg的第一和第二拷贝，其中HBcAg的一个或两个拷贝具有连接到e1环上的糖。 第一拷贝可以具有与e1环连接的糖，第二拷贝可以包含e1环中的肽表位。 该蛋白质可用于诱导针对糖的免疫应答，因此用作疫苗。