公开(公告)号：US20160136197A1

公开(公告)日：2016-05-19

申请号：US14898000

申请日：2014-06-13

申请人： INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

发明人： Carla Christina Schrier ,  Martijn BROK DEN ,  Gosse Adema

IPC分类号： A61K31/7088 ,  A61K31/7084

CPC分类号： A61K31/7088 ,  A61K31/7084 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions comprising an immunostimulatory amount of at least two immunopotentiators, wherein a first immunopotentiator is a non-methylated cytidyl guanosyl oligodeoxynucleotide (CpG ODN) and a second immunopotentiator is 3′,5′-cyclic diguanylic acid (c-di-GMP), and a pharmaceutically acceptable carrier. The invention also relates to the use of such pharmaceutical compositions for the induction of an immune response against tumor-specific antigens. Also the invention relates to their use in in situ tumor-destruction therapy and to such pharmaceutical compositions for use in the treatment of a mammal suffering from cancer.

摘要翻译： 本发明涉及包含免疫刺激量的至少两种免疫增强剂的药物组合物，其中第一免疫增强剂是非甲基化胞苷酰鸟嘌呤寡脱氧核苷酸（CpG ODN），第二免疫增强剂是3'，5'-环状二羟基酸（c- di-GMP）和药学上可接受的载体。 本发明还涉及这种药物组合物用于诱导针对肿瘤特异性抗原的免疫应答的用途。 本发明还涉及其在原位肿瘤破坏治疗中的用途以及用于治疗患有癌症的哺乳动物的这种药物组合物。