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公开(公告)号：US20190134210A1
公开(公告)日：2019-05-09
申请号：US15807602
申请日：2017-11-09
发明人： Dylan BODAY , Wei CHENG , Jeannette M. GARCIA , James HEDRICK , Nathaniel H. PARK , Rudy J. WOJTECKI , Chuan YANG , Yi Yan YANG
IPC分类号： A61K47/60 , A61P35/00 , A61K31/785 , A61K47/69
摘要： Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.
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公开(公告)号：US20170327645A1
公开(公告)日：2017-11-16
申请号：US15153079
申请日：2016-05-12
CPC分类号： C08G75/04 , C08G73/02 , C08K3/38 , C08K2003/387
摘要： Compounds include boronate ester polythioaminals with substituents that include hydrogen, fluorine or substituted or unsubstituted alkyls. The boronate ester polythioaminals have number average molecular weight or weight average molecular weight between about 2,000 to about 160,000.
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公开(公告)号：US20170226290A1
公开(公告)日：2017-08-10
申请号：US15016610
申请日：2016-02-05
IPC分类号： C08G73/06
CPC分类号： C08G73/0644 , C08G12/08 , C08G73/065 , G03F7/038 , G03F7/20 , G03F7/30
摘要： This disclosure describes new compositions and methods related to photoresponsive poly(hexahydrotriazines) and related polymers.
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公开(公告)号：US20170183451A1
公开(公告)日：2017-06-29
申请号：US15460785
申请日：2017-03-16
CPC分类号： C08G73/0644 , C07D207/452 , C08G73/065 , C08G73/1039 , C08G73/1064 , C08G73/1067 , C08L63/00 , C08L63/04 , C08L79/04 , C08L79/08
摘要： In some embodiments, a product, such as a thermoset, has a polyhexahydrotriazine and a self-polymerized cross-linkable polymer. In some embodiments, a product is the reaction product of a diamine, an aldehyde, and a compound having an α,β-unsaturated electron withdrawing moiety.
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公开(公告)号：US20170137572A1
公开(公告)日：2017-05-18
申请号：US15157224
申请日：2016-05-17
IPC分类号： C08G75/02
CPC分类号： C08G75/02
摘要： Thioaminal polymers are made from hexahydrotriazine precursors and dithiol precursors. The precursors are blended together and subjected to mild heating to make the polymers. An amine scavenger is used to remove amine byproducts from the reaction, thus promoting polymer growth to high molecular weight. The polymers have the general structure wherein each R1 is independently an organic or hetero-organic group, a plurality of R2 groups are substituents having molecular weight greater than about 120 Daltons, and n is an integer greater than or equal to 1. The polymers may be functionalized by adding a thiol-reactive group to either end or both ends.
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公开(公告)号：US20170121461A1
公开(公告)日：2017-05-04
申请号：US15287419
申请日：2016-10-06
IPC分类号： C08G75/02 , C08G75/0236
CPC分类号： C08G75/0272 , C08G75/0236 , C08G75/04
摘要： Compounds include polythioaminals of the formula: Each instance of R may be hydrogen or an electron withdrawing group. ‘n’ may be an integer such that the number average molecular weight (Mn) or weight average molecular weight (Mw) is between about 2,000 to about 80,000. Compounds also include polythioaminals of the formula: Each instance of R may be independently selected from the group consisting of —H, —F, —CF3, and —NO2. Each instance of R′ may be independently selected from the group consisting of cycloalkyl, alkyl, alkylene glycol, acrylate, and siloxane. ‘n’ may be an integer such that the number average molecular weight (Mn) or weight average molecular weight (Mw) is between about 2,000 to about 80,000.
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公开(公告)号：US20170121445A1
公开(公告)日：2017-05-04
申请号：US15353451
申请日：2016-11-16
IPC分类号： C08G12/06 , C08G12/00 , C07C251/18 , C08G12/08 , C07C251/24 , C07C251/04
CPC分类号： C08G12/06 , C07C251/04 , C07C251/08 , C07C251/18 , C07C251/24 , C07C2101/14 , C07C2601/14 , C08G12/00 , C08G12/08
摘要： Methods, compounds, and compositions described herein generally relate to polyalkylamines and syntheses thereof. In some embodiments, a chemical compound has the formula: Each instance of R is independently selected from the group consisting of aryl, alkyl, and polyether. Each instance of R′ is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, polyether, and alcohol. Each instance of Q and Z is independently a covalent bond or selected from the group consisting of alkyl and aralkyl.
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公开(公告)号：US20170107328A1
公开(公告)日：2017-04-20
申请号：US15249218
申请日：2016-08-26
IPC分类号： C08G75/02
摘要： The disclosure describes new compositions and methods related to polyaminals and related polymers. The compositions are useful as therapeutic/drug conjugates, self-healing materials, reversible crosslinking materials, degradable hydrogels, protective coatings, and as metal scavenging agents. New atom efficient synthetic schemes are disclosed, which yield previously unobtainable high molecular weight polyaminals.
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公开(公告)号：US20170096532A1
公开(公告)日：2017-04-06
申请号：US15334156
申请日：2016-10-25
IPC分类号： C08G75/04
摘要： The disclosure describes new compositions and methods related to polyaminals and related polymers. The compositions are useful as therapeutic/drug conjugates, self-healing materials, reversible crosslinking materials, degradable hydrogels, protective coatings, and as metal scavenging agents. New atom efficient synthetic schemes are disclosed, which yield previously unobtainable high molecular weight polyaminals.
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公开(公告)号：US20170065722A1
公开(公告)日：2017-03-09
申请号：US14844561
申请日：2015-09-03
IPC分类号： A61K47/48
CPC分类号： A61K47/59 , A61K47/20 , A61K47/56 , A61K47/6923 , A61K47/6929 , A61K49/0002 , A61K49/0017 , A61K49/0065 , C08G73/0253
摘要： A functionalized nanomaterial, such as a nanoparticle, can include a polythioaminal functionalized surface. The polythioaminal linked to the surface of the nanomaterial can be bonded to a compound such as therapeutic and/or diagnostic materials. The thiol-based linkages can be used to bond the polythioaminal to both the nanomaterial and the therapeutic and/or diagnostic materials. Polythioaminals can be prepared via reactions of triazine and dithiols. Polythioaminals thus prepared can be further modified to provide linkages to the nanomaterial and other compounds such as medicinal compound, peptides, and dyes. Nanomaterials including such compounds linked thereto via the polythioaminal can be supplied for therapeutic and/or diagnostic purposes to biological target regions.
摘要翻译： 功能化纳米材料，例如纳米颗粒，可以包括聚硫代氨基官能化表面。 与纳米材料表面连接的聚硫代胺可以与化合物如治疗和/或诊断材料结合。 硫醇基键可以用于将聚硫代胺结合到纳米材料和治疗和/或诊断材料两者。 聚硫代胺可以通过三嗪和二硫醇的反应制备。 如此制备的聚硫代胺可进一步修饰以提供与纳米材料和其它化合物如药用化合物，肽和染料的连接。 包括通过聚硫代胺连接的这类化合物的纳米材料可以用于生物靶区域的治疗和/或诊断目的。
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