专利检索 ap:("INSERM" OR "UNIVERSITÉ PARIS DIDEROT - PARIS 7") AND inv:"Søren Christensen" 第 1 页

1.

发明授权
Immunological treatment of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 有权

公开(公告)号：US10407500B2

公开(公告)日：2019-09-10

申请号：US15514173

申请日：2015-09-18

申请人： INSERM , UNIVERSITÉ PARIS DIDEROT—PARIS 7

发明人： Anne Joutel , Søren Christensen , Thorleif Jan Pedersen

IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , A61K39/00 , C07K14/705 , C07K14/71

摘要： The present invention relates to an anti-Notch 3 antibody therapy useful for treatment of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. In particular, the invention relates to an anti-Notch3 antibody or a fragment thereof having a 2 fold, 4 fold or 10 fold higher affinity to Notch 3 than to Notch 1 or Notch 2 for use in therapy.

2.

发明申请
IMMUNOLOGICAL TREATMENT OF CEREBRAL AUTOSOMAL DOMINANT ARTERIOPATHY WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY 审中-公开

公开(公告)号：US20200048342A1

公开(公告)日：2020-02-13

申请号：US16519683

申请日：2019-07-23

申请人： INSERM , UNIVERSITÉ PARIS DIDEROT - PARIS 7

发明人： Anne Joutel , Søren Christensen , Thorleif Jan Pedersen

IPC分类号： C07K16/28 , A61K39/395 , A61K39/00

摘要： The present invention relates to an anti-Notch 3 antibody therapy useful for treatment of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. In particular, the invention relates to an anti-Notch3 antibody or a fragment thereof having a 2 fold, 4 fold or 10 fold higher affinity to Notch 3 than to Notch 1 or Notch 2 for use in therapy.