公开(公告)号：US20200222711A1

公开(公告)日：2020-07-16

申请号：US16728803

申请日：2019-12-27

申请人： IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

发明人： Harold WALDER ,  Frederic A. Bourke, JR. ,  Zakaryae Fathi ,  Wayne F. Beyer, JR. ,  Mark Dewhirst ,  Mark Oldham ,  Justus Adamson ,  Michael Nolan

IPC分类号： A61N5/06 ,  A61K41/17 ,  A61K39/00 ,  A61K41/00 ,  A61K49/04 ,  A61N5/02 ,  A61N5/10

摘要： A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.

公开(公告)号：US20160331731A1

公开(公告)日：2016-11-17

申请号：US15220596

申请日：2016-07-27

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Wenle XIA ,  David Gooden ,  Erik J. Soderblom ,  Eric J. Toone ,  Neil L. Spector ,  Wayne F. Beyer, JR. ,  Harold Walder

IPC分类号： A61K31/436 ,  A61K31/4709 ,  A61K41/00 ,  A61K45/06

CPC分类号： A61K31/436 ,  A61K31/37 ,  A61K31/4709 ,  A61K31/517 ,  A61K41/0066 ,  A61K45/06 ,  A61K2300/00

摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.

公开(公告)号：US20210145028A1

公开(公告)日：2021-05-20

申请号：US17135479

申请日：2020-12-28

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. BOURKE, JR. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, JR.

IPC分类号： A23L3/28 ,  A23L3/26 ,  A61L2/08 ,  A61M1/36 ,  C02F1/32 ,  G03F7/20 ,  A61N5/06 ,  A61L2/00 ,  C23C16/458

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US20140272030A1

公开(公告)日：2014-09-18

申请号：US14206337

申请日：2014-03-12

申请人： IMMUNOLIGHT, LLC.

发明人： Frederic Avery Bourke, JR. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, JR.

IPC分类号： G21K5/02 ,  A61N5/10 ,  G03F7/20 ,  A23L3/26 ,  C02F1/30 ,  A61M1/36 ,  C02F1/32 ,  A23L3/28 ,  B05D3/06 ,  A61L2/08

CPC分类号： A23L3/28 ,  A23L3/263 ,  A23V2002/00 ,  A61L2/0041 ,  A61L2/0047 ,  A61L2/08 ,  A61L2/082 ,  A61L2202/24 ,  A61M1/3681 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  C02F1/307 ,  C02F1/32 ,  C02F1/325 ,  C02F2201/32 ,  C02F2305/10 ,  C23C16/458 ,  G03F7/20 ,  Y02W10/37

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

摘要翻译： 一种用于产生介质变化的方法和系统。 该方法在介质附近放置能量调节剂。 该方法对介质施加引发能量。 引发能与能量调节剂相互作用直接或间接产生介质中的变化。 能量调节剂具有在已知产生变化的第二波长范围（WR2）之外的第一波长范围内的辐射的正常主要发射，但是在暴露于所施加的引发能量的同时产生变化。 该系统包括引发能量源，其被配置为向介质施加引发能量以激活能量调节剂。