公开(公告)号：US20220062419A1

公开(公告)日：2022-03-03

申请号：US17227753

申请日：2021-04-12

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Mark OLDHAM ,  Justus ADAMSON ,  Mark W. DEWHIRST ,  Paul YOON ,  Harold WALDER ,  Frederic A. Bourke, JR. ,  Zakaryae FATHI ,  Wayne F. BEYER, JR.

IPC: A61K41/00 ,  A61N5/06 ,  A61K31/655 ,  A61K33/02 ,  A61K31/409 ,  A61K31/525 ,  A61K31/352 ,  A61K31/403 ,  A61K33/242 ,  A61K33/244 ,  A61K33/24 ,  A61N5/10

Abstract: A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.

公开(公告)号：US20200368547A1

公开(公告)日：2020-11-26

申请号：US16860623

申请日：2020-04-28

Applicant: IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

Inventor： Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zakaryae FATHI ,  Michael J. THERIEN ,  Mark W. DEWHIRST ,  Ian N. STANTON ,  Jennifer Ann AYRES ,  Diane Renee FELS ,  Joseph A. HERBERT

IPC: A61N5/06 ,  A61K41/00 ,  A61N5/10

Abstract: A method for treating a disease, disorder, or condition in a subject in need thereof, by administering either or both of (i) at least one photoactivatable pharmaceutical agent, or (ii) a first plurality of energy-emitting particles, into the subject in a region of the disease, disorder, or condition, whereby the administering is performed through inhalation; and applying an applied electromagnetic energy to the subject, wherein the applied electromagnetic energy directly or indirectly activates the at least one photoactivatable pharmaceutical agent, when present, and wherein when the first plurality of energy-emitting particles is present, the first plurality of energy-emitting particles absorbs the applied energy and emits an emitted electromagnetic energy, wherein the emitted electromagnetic energy interacts directly with the region of the disease, disorder, or condition or activates the at least one photoactivatable pharmaceutical agent.

公开(公告)号：US20180311355A1

公开(公告)日：2018-11-01

申请号：US15770926

申请日：2016-10-26

Applicant: IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

Inventor： Mark OLDHAM ,  Justus ADAMSON ,  Mark W. DEWHIRST ,  Paul YOON ,  Harold WALDER ,  Frederic A. BOURKE ,  Zakaryae FATHI ,  Wayne F. BEYER

IPC: A61K41/00 ,  A61N5/06 ,  A61K33/24 ,  A61N5/10

CPC classification number: A61K31/655 ,  A61K31/352 ,  A61K31/403 ,  A61K31/409 ,  A61K31/525 ,  A61K33/02 ,  A61K41/0066 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/065 ,  A61N2005/1095 ,  A61N2005/1098 ,  Y02A50/393

Abstract: A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.

公开(公告)号：US20170050046A1

公开(公告)日：2017-02-23

申请号：US15307766

申请日：2015-04-22

Applicant: IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY ,  NORTH CAROLINA STATE UNIVERSITY

Inventor： Harold WALDER ,  Frederic A. BOURKE ,  Zakaryae FATHI ,  Wayne F. BEYER ,  Mark W. DEWHIRST ,  Mark OLDHAM ,  Justus ADAMSON ,  Michael NOLAN

IPC: A61N5/06 ,  A61B6/00 ,  A61N5/10 ,  A61K9/00 ,  A61K49/04 ,  A61K41/00 ,  A61K39/00 ,  A61B6/03 ,  A61N5/02

CPC classification number: A61N5/062 ,  A61K39/0011 ,  A61K41/0019 ,  A61K41/0066 ,  A61K49/0423 ,  A61K2039/585 ,  A61N5/022 ,  A61N5/10 ,  A61N5/1081 ,  A61N2005/0627 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1089 ,  A61N2005/1098

Abstract: A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photo-activatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.

Abstract translation: 用于在人或动物体内成像或治疗疾病的系统和方法。 该系统向人体或动物体提供包含能够将紫外线或可见光发射到体内并提供x射线对比度的一种或多种磷光体的药物载体。 该系统包括一个或多个装置，其将病变部位注入可光活化药物和药物载体，引发能量源包括用X射线或高能量源照射患病部位的x射线， 伽马射线或电子，从而开始将所述紫外线或可见光发射到体内;以及处理器，被编程为以下中的至少一个：1）产生患病部位的图像，或2）控制所述X射线，γ射线的剂量 或电子到病变部位，以在病变部位产生所述紫外线或可见光，以活化可光活化药物。